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Cationic type I amphiphiles as modulators of membrane curvature elastic stress in vivo

Cationic type I amphiphiles as modulators of membrane curvature elastic stress in vivo
Cationic type I amphiphiles as modulators of membrane curvature elastic stress in vivo
Recently we proposed that the antineoplastic properties observed in vivo for alkyl-lysophospholipid and alkylphosphocholine analogues are a direct consequence of the reduction of membrane stored elastic stress induced by these amphiphiles. Here we report similar behavior for a wide range of cationic surfactant analogues. Our systematic structure?activity studies show that the cytotoxic properties of cationic surfactants follow the same pattern of activity we observed previously for alkyl-lysophospholipid analogues, indicating a common mechanism of action that is consistent with the theory that these amphiphiles reduce membrane stored elastic stress. We note that several of the cationic surfactant compounds we have evaluated are also potent antibacterial and antifungal agents. The similarity of structure?activity relationships for cationic surfactants against microorganisms and those we have observed in eukaryotic cell lines leads us to suggest the possibility that the antibacterial and antifungal properties of cationic surfactants may also be due to modulation of membrane stored elastic stress.
0743-7463
11743-11751
Dymond, Marcus K.
e180765b-039e-47ff-9841-ce6a5123a519
Attard, George S.
3219075d-2364-4f00-aeb9-1d90f8cd0d36
Dymond, Marcus K.
e180765b-039e-47ff-9841-ce6a5123a519
Attard, George S.
3219075d-2364-4f00-aeb9-1d90f8cd0d36

Dymond, Marcus K. and Attard, George S. (2008) Cationic type I amphiphiles as modulators of membrane curvature elastic stress in vivo. Langmuir, 24 (20), 11743-11751. (doi:10.1021/la8017612).

Record type: Article

Abstract

Recently we proposed that the antineoplastic properties observed in vivo for alkyl-lysophospholipid and alkylphosphocholine analogues are a direct consequence of the reduction of membrane stored elastic stress induced by these amphiphiles. Here we report similar behavior for a wide range of cationic surfactant analogues. Our systematic structure?activity studies show that the cytotoxic properties of cationic surfactants follow the same pattern of activity we observed previously for alkyl-lysophospholipid analogues, indicating a common mechanism of action that is consistent with the theory that these amphiphiles reduce membrane stored elastic stress. We note that several of the cationic surfactant compounds we have evaluated are also potent antibacterial and antifungal agents. The similarity of structure?activity relationships for cationic surfactants against microorganisms and those we have observed in eukaryotic cell lines leads us to suggest the possibility that the antibacterial and antifungal properties of cationic surfactants may also be due to modulation of membrane stored elastic stress.

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e-pub ahead of print date: 17 September 2008
Published date: 21 October 2008
Organisations: Chemistry

Identifiers

Local EPrints ID: 147787
URI: http://eprints.soton.ac.uk/id/eprint/147787
ISSN: 0743-7463
PURE UUID: 3b85aa1c-787b-4c1e-aaa4-9182baa7a5f4
ORCID for George S. Attard: ORCID iD orcid.org/0000-0001-8304-0742

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Date deposited: 27 Apr 2010 08:16
Last modified: 20 Jul 2019 01:21

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