The University of Southampton
University of Southampton Institutional Repository

Agomelatine improves symptoms of generalised anxiety disorder

Baldwin, David S. and Lopes, Antonio T. (2009) Agomelatine improves symptoms of generalised anxiety disorder Evidence-Based Mental Health, 12, (2), p. 54. (doi:10.1136/ebmh.12.2.54).

Record type: Article



Is agomelatine effective for people with generalised anxiety disorder?


121 people, aged 18–65 years, with DSM-IV generalised anxiety disorder (69% female, mean age 42 years) (see online notes for exclusion criteria).


Five centres in Finland and six centres in South Africa; time period not stated.


Agomelatine (n?=?63; 25–50 mg/day) or placebo (n?=?58) for 12 weeks. Agomelatine dose was increased from 25 to 50 mg/day if there was an insufficient response after 2 weeks. This was done in a blinded fashion, using a dose adjustment algorithm.


Primary outcome: overall anxiety (HAM-A). Secondary outcomes: response (?50% reduction in HAM-A score); somatic anxiety, psychic anxiety, severity of illness, sleep and disability symptoms (HAM-A subscales, Clinical Global Impressions Scale, Leeds Sleep Evaluation Questionnaire and Sheehan Disability Scale); discontinuation effects in the week after discontinuation (Discontinuation Emergent Signs and Symptoms scale (DESS)).

Full text not available from this repository.

More information

Published date: 2009


Local EPrints ID: 148101
ISSN: 1362-0347
PURE UUID: c31ef972-16b4-4e02-ab05-05a9929e5109

Catalogue record

Date deposited: 27 Apr 2010 11:00
Last modified: 18 Jul 2017 19:32

Export record


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.