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The synthesis and in vivo evaluation of 2,2-difluoro KRN7000

Record type: Article

The synthesis of 2,2-difluoro KRN7000 is described. In vivo evaluation demonstrates that this fluorinated glycolipid induces CD1d-dependent TCR activation of NKT cells, with a bias towards Th2 cytokine production.

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Citation

Leung, Leo, Tomassi, Cyrille, Van Beneden, Katrien, Decruy, Tine, Trappeniers, Matthias, Elewaut, Dirk, Gao, Yifang, Elliott, Tim, Al-Shamkhani, Aymen, Ottensmeier, Christian, Werner, Jörn M., Williams, Anthony, Van Calenbergh, Serge and Linclau, Bruno (2009) The synthesis and in vivo evaluation of 2,2-difluoro KRN7000 ChemMedChem, 4, (3), 329 -334. (doi:10.1002/cmdc.200800348).

More information

Published date: 16 March 2009
Keywords: galactosylceramide, cytokines, fluorination, glycolipids, NKT cells
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 148257
URI: http://eprints.soton.ac.uk/id/eprint/148257
ISSN: 1860-7179
PURE UUID: f21db676-d572-4399-90d6-b040c9505aec
ORCID for Tim Elliott: ORCID iD orcid.org/0000-0003-1097-0222
ORCID for Jörn M. Werner: ORCID iD orcid.org/0000-0002-4712-1833
ORCID for Bruno Linclau: ORCID iD orcid.org/0000-0001-8762-0170

Catalogue record

Date deposited: 27 Apr 2010 14:20
Last modified: 18 Jul 2017 19:32

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Contributors

Author: Leo Leung
Author: Cyrille Tomassi
Author: Katrien Van Beneden
Author: Tine Decruy
Author: Matthias Trappeniers
Author: Dirk Elewaut
Author: Yifang Gao
Author: Tim Elliott ORCID iD
Author: Jörn M. Werner ORCID iD
Author: Serge Van Calenbergh
Author: Bruno Linclau ORCID iD

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