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The synthesis and in vivo evaluation of 2,2-difluoro KRN7000

The synthesis and in vivo evaluation of 2,2-difluoro KRN7000
The synthesis and in vivo evaluation of 2,2-difluoro KRN7000
The synthesis of 2,2-difluoro KRN7000 is described. In vivo evaluation demonstrates that this fluorinated glycolipid induces CD1d-dependent TCR activation of NKT cells, with a bias towards Th2 cytokine production.
galactosylceramide, cytokines, fluorination, glycolipids, NKT cells
1860-7179
329 -334
Leung, Leo
bc749c61-15c6-4c7c-9396-db2c93ac3fd9
Tomassi, Cyrille
51fbf42e-4b91-481c-8528-95ca06e30c40
Van Beneden, Katrien
d8fc2c97-163b-4422-a513-34a08745a00c
Decruy, Tine
0d799625-7310-423a-b7a7-6ece86b8ea1a
Trappeniers, Matthias
003338a8-2d89-453c-86ee-67c7464e1ac3
Elewaut, Dirk
98c0d9e0-e559-4f19-8a56-573fee3da83e
Gao, Yifang
d209d667-ef6e-4a24-ab7d-2f52c618361f
Elliott, Tim
16670fa8-c2f9-477a-91df-7c9e5b453e0e
Al-Shamkhani, Aymen
0a40b3ce-9d71-4d41-9369-7212f0a84504
Ottensmeier, Christian
42b8a398-baac-4843-a3d6-056225675797
Werner, Jörn M.
1b02513a-8310-4f4f-adac-dc2a466bd115
Williams, Anthony
973ff46f-46f1-4d7c-b27d-0f53221e4c44
Van Calenbergh, Serge
9587a6e2-b48b-4f79-807d-b889c7a1d9d6
Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba
Leung, Leo
bc749c61-15c6-4c7c-9396-db2c93ac3fd9
Tomassi, Cyrille
51fbf42e-4b91-481c-8528-95ca06e30c40
Van Beneden, Katrien
d8fc2c97-163b-4422-a513-34a08745a00c
Decruy, Tine
0d799625-7310-423a-b7a7-6ece86b8ea1a
Trappeniers, Matthias
003338a8-2d89-453c-86ee-67c7464e1ac3
Elewaut, Dirk
98c0d9e0-e559-4f19-8a56-573fee3da83e
Gao, Yifang
d209d667-ef6e-4a24-ab7d-2f52c618361f
Elliott, Tim
16670fa8-c2f9-477a-91df-7c9e5b453e0e
Al-Shamkhani, Aymen
0a40b3ce-9d71-4d41-9369-7212f0a84504
Ottensmeier, Christian
42b8a398-baac-4843-a3d6-056225675797
Werner, Jörn M.
1b02513a-8310-4f4f-adac-dc2a466bd115
Williams, Anthony
973ff46f-46f1-4d7c-b27d-0f53221e4c44
Van Calenbergh, Serge
9587a6e2-b48b-4f79-807d-b889c7a1d9d6
Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba

Leung, Leo, Tomassi, Cyrille, Van Beneden, Katrien, Decruy, Tine, Trappeniers, Matthias, Elewaut, Dirk, Gao, Yifang, Elliott, Tim, Al-Shamkhani, Aymen, Ottensmeier, Christian, Werner, Jörn M., Williams, Anthony, Van Calenbergh, Serge and Linclau, Bruno (2009) The synthesis and in vivo evaluation of 2,2-difluoro KRN7000 ChemMedChem, 4, (3), 329 -334. (doi:10.1002/cmdc.200800348).

Record type: Article

Abstract

The synthesis of 2,2-difluoro KRN7000 is described. In vivo evaluation demonstrates that this fluorinated glycolipid induces CD1d-dependent TCR activation of NKT cells, with a bias towards Th2 cytokine production.

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More information

Published date: 16 March 2009
Keywords: galactosylceramide, cytokines, fluorination, glycolipids, NKT cells
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 148257
URI: http://eprints.soton.ac.uk/id/eprint/148257
ISSN: 1860-7179
PURE UUID: f21db676-d572-4399-90d6-b040c9505aec
ORCID for Tim Elliott: ORCID iD orcid.org/0000-0003-1097-0222
ORCID for Jörn M. Werner: ORCID iD orcid.org/0000-0002-4712-1833
ORCID for Bruno Linclau: ORCID iD orcid.org/0000-0001-8762-0170

Catalogue record

Date deposited: 27 Apr 2010 14:20
Last modified: 18 Jul 2017 19:32

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Contributors

Author: Leo Leung
Author: Cyrille Tomassi
Author: Katrien Van Beneden
Author: Tine Decruy
Author: Matthias Trappeniers
Author: Dirk Elewaut
Author: Yifang Gao
Author: Tim Elliott ORCID iD
Author: Jörn M. Werner ORCID iD
Author: Serge Van Calenbergh
Author: Bruno Linclau ORCID iD

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