The synthesis and in vivo evaluation of 2,2-difluoro KRN7000

Leung, Leo, Tomassi, Cyrille, Van Beneden, Katrien, Decruy, Tine, Trappeniers, Matthias, Elewaut, Dirk, Gao, Yifang, Elliott, Tim, Al-Shamkhani, Aymen, Ottensmeier, Christian, Werner, Jörn M., Williams, Anthony, Van Calenbergh, Serge and Linclau, Bruno (2009) The synthesis and in vivo evaluation of 2,2-difluoro KRN7000 ChemMedChem, 4, (3), 329 -334. (doi:10.1002/cmdc.200800348).


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The synthesis of 2,2-difluoro KRN7000 is described. In vivo evaluation demonstrates that this fluorinated glycolipid induces CD1d-dependent TCR activation of NKT cells, with a bias towards Th2 cytokine production.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1002/cmdc.200800348
ISSNs: 1860-7179 (print)
Related URLs:
Keywords: galactosylceramide, cytokines, fluorination, glycolipids, NKT cells
Subjects: R Medicine > R Medicine (General)
ePrint ID: 148257
Date :
Date Event
16 March 2009Published
Date Deposited: 27 Apr 2010 14:20
Last Modified: 18 Apr 2017 14:34
Further Information:Google Scholar

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