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Facile, one-step production of niacin (Vitamin B-3) and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst

Facile, one-step production of niacin (Vitamin B-3) and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst
Facile, one-step production of niacin (Vitamin B-3) and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst
Niacin (3-picolinic acid), which is extensively used as vitamin B3 in foodstuffs and as a cholesterol-lowering agent, along with other oxygenated products of the picolines, 4-methylquinoline, and a variety of pyrimidines and pyridazines, may be produced in a single-step, environmentally benign fashion by combining single-site, open-structure, heterogeneous catalysts with a solid source of active oxygen, namely acetyl peroxyborate (APB), in the absence of an organic solvent. The high activities, selectivities, and the relatively mild conditions employed with this single-site heterogeneous catalyst, coupled with ease of transport, storage, and stability of the solid oxidant, augurs well for the future use of APB in conjunction with other open-structure, single-site catalysts for fine-chemical, pharmaceutical, and agrochemical applications.
oxidation, system, design, selective oxidation, cyclohexane, adipic acid, mesoporous materials, heterogeneous catalysis, chemistry, performance, acetyl peroxyborate green, solids
0947-6539
2340-2348
Raja, Robert
74faf442-38a6-4ac1-84f9-b3c039cb392b
Thomas, John Meurig
f1d9bb61-4e2c-4c4b-8115-953d0f3d36bd
Greenhill-Hooper, Michael
f17a45fd-cb9a-4a81-bc65-5e4816e510a5
Ley, Steven V.
48cb1588-8a3c-4d40-a35d-bc349b403df4
Paz, Filipe A. Almeida
b89c2799-d876-4a39-a4a0-29ca0beca719
Raja, Robert
74faf442-38a6-4ac1-84f9-b3c039cb392b
Thomas, John Meurig
f1d9bb61-4e2c-4c4b-8115-953d0f3d36bd
Greenhill-Hooper, Michael
f17a45fd-cb9a-4a81-bc65-5e4816e510a5
Ley, Steven V.
48cb1588-8a3c-4d40-a35d-bc349b403df4
Paz, Filipe A. Almeida
b89c2799-d876-4a39-a4a0-29ca0beca719

Raja, Robert, Thomas, John Meurig, Greenhill-Hooper, Michael, Ley, Steven V. and Paz, Filipe A. Almeida (2008) Facile, one-step production of niacin (Vitamin B-3) and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst. Chemistry - A European Journal, 14 (8), 2340-2348. (doi:10.1002/chem.200701679).

Record type: Article

Abstract

Niacin (3-picolinic acid), which is extensively used as vitamin B3 in foodstuffs and as a cholesterol-lowering agent, along with other oxygenated products of the picolines, 4-methylquinoline, and a variety of pyrimidines and pyridazines, may be produced in a single-step, environmentally benign fashion by combining single-site, open-structure, heterogeneous catalysts with a solid source of active oxygen, namely acetyl peroxyborate (APB), in the absence of an organic solvent. The high activities, selectivities, and the relatively mild conditions employed with this single-site heterogeneous catalyst, coupled with ease of transport, storage, and stability of the solid oxidant, augurs well for the future use of APB in conjunction with other open-structure, single-site catalysts for fine-chemical, pharmaceutical, and agrochemical applications.

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More information

Published date: 28 January 2008
Keywords: oxidation, system, design, selective oxidation, cyclohexane, adipic acid, mesoporous materials, heterogeneous catalysis, chemistry, performance, acetyl peroxyborate green, solids
Organisations: Chemistry

Identifiers

Local EPrints ID: 148289
URI: http://eprints.soton.ac.uk/id/eprint/148289
ISSN: 0947-6539
PURE UUID: d5bb5661-281f-431c-b58a-fe4ab8b67b2c
ORCID for Robert Raja: ORCID iD orcid.org/0000-0002-4161-7053

Catalogue record

Date deposited: 28 Apr 2010 08:45
Last modified: 10 Dec 2019 01:43

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Contributors

Author: Robert Raja ORCID iD
Author: John Meurig Thomas
Author: Michael Greenhill-Hooper
Author: Steven V. Ley
Author: Filipe A. Almeida Paz

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