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Association analysis of monoamine oxidase A and attention deficit hyperactivity disorder

Lawson, Deborah C., Turic, Darko, Langley, Kate, Pay, Helen M., Govan, Catherine F., Norton, Nadine, Hamshere, Marian L., Owen, Michael J., O'Donovan, Michael C. and Thapar, Anita (2002) Association analysis of monoamine oxidase A and attention deficit hyperactivity disorder American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 116B, (1), pp. 84-89. (doi:10.1002/ajmg.b.10002).

Record type: Article


Attention deficit hyperactivity disorder (ADHD) is a highly heritable disorder. Although the causes of ADHD are unknown, dopaminergic, serotonergic and nor-adrenergic pathways have been strongly implicated. Monoamine Oxidase A (MAOA) is involved in the degradation of all three of these neurotransmitters and therefore has been suggested as a strong candidate gene for ADHD.

Animal and human studies have implicated MAOA and 5-HT in impulsive and aggressive behavior. We therefore additionally postulated that MAOA might be associated with a subtype of ADHD where aggressive and impulsive features are especially prominent. We have tested this hypothesis by genotyping two polymorphisms (the 30-bp VNTR in the promoter and the Fnu4HI 941TG) in MAOA that are associated with altered MAOA function.

Our sample consisted of 171 British Caucasian children 6-16 years of age fulfilling DSM-III R, DSM-IV or ICD-10 criteria for ADHD/Hyperkinetic Disorder. Using case control analysis and then the TDT, no association was found between these two MAOA polymorphisms and ADHD. Case control analysis of the VNTR showed an association with a subgroup of children with comorbid conduct problems (OR = 2.0, 95% CI = 1.09, 3.5), and TDT analysis indicated a statistical trend toward association.
Our findings highlight the importance of phenotype definition and the need for the MAOA VNTR to be further examined.

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Published date: 19 December 2002
Keywords: attention deficit hyperactivity disorder, hyperkinetic disorder, monoamine oxidase A, impulsive aggressive behavior, conduct disorders MAO-A, ADHD


Local EPrints ID: 148335
ISSN: 1552-4841
PURE UUID: 405a7c9c-cc6a-4e59-9d34-ec2f794d140d

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Date deposited: 08 Jul 2010 14:32
Last modified: 18 Jul 2017 19:32

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Author: Deborah C. Lawson
Author: Darko Turic
Author: Kate Langley
Author: Helen M. Pay
Author: Catherine F. Govan
Author: Nadine Norton
Author: Marian L. Hamshere
Author: Michael J. Owen
Author: Michael C. O'Donovan
Author: Anita Thapar

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