Synthesis and in vitro evaluation of ?-GalCer epimers
Synthesis and in vitro evaluation of ?-GalCer epimers
?-GalCer (also known as KRN7000) is an immunomodulatory glycolipid that is known to potently activate invariant natural killer T (NKT) cells upon CD1d-mediated stimulation. Because Th1 and Th2 cytokines, which are released after ?-GalCer presentation, antagonize each other's effects, ?-GalCer analogues that induce a biased Th1/Th2 response are highly awaited. In this context, we report the synthesis and in vitro evaluation of ?-Gal-D-xylo-Cer and two ?-Gal-L-lyxo-Cer analogues, one with the natural acyl chain, the other with a truncated chain.
?-galactosylceramide, cytokines, epimers, glycolipids, NKT cells
1061-1070
Trappeniers, Matthias
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Goormans, Stijn
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Van Beneden, Katrien
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Decruy, Tine
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Linclau, Bruno
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Al-Shamkhani, Aymen
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Elliott, Tim
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Ottensmeier, Christian
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Werner, Joern M.
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Elewaut, Dirk
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Van Calenbergh, Serge
9587a6e2-b48b-4f79-807d-b889c7a1d9d6
14 July 2008
Trappeniers, Matthias
003338a8-2d89-453c-86ee-67c7464e1ac3
Goormans, Stijn
b51ab85e-b3cc-4ae3-b02d-322d15400b86
Van Beneden, Katrien
d8fc2c97-163b-4422-a513-34a08745a00c
Decruy, Tine
0d799625-7310-423a-b7a7-6ece86b8ea1a
Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba
Al-Shamkhani, Aymen
0a40b3ce-9d71-4d41-9369-7212f0a84504
Elliott, Tim
16670fa8-c2f9-477a-91df-7c9e5b453e0e
Ottensmeier, Christian
42b8a398-baac-4843-a3d6-056225675797
Werner, Joern M.
fba7b358-19b5-437f-bf17-47250953b1d9
Elewaut, Dirk
98c0d9e0-e559-4f19-8a56-573fee3da83e
Van Calenbergh, Serge
9587a6e2-b48b-4f79-807d-b889c7a1d9d6
Trappeniers, Matthias, Goormans, Stijn, Van Beneden, Katrien, Decruy, Tine, Linclau, Bruno, Al-Shamkhani, Aymen, Elliott, Tim, Ottensmeier, Christian, Werner, Joern M., Elewaut, Dirk and Van Calenbergh, Serge
(2008)
Synthesis and in vitro evaluation of ?-GalCer epimers.
ChemMedChem, 3 (7), .
(doi:10.1002/cmdc.200800021).
Abstract
?-GalCer (also known as KRN7000) is an immunomodulatory glycolipid that is known to potently activate invariant natural killer T (NKT) cells upon CD1d-mediated stimulation. Because Th1 and Th2 cytokines, which are released after ?-GalCer presentation, antagonize each other's effects, ?-GalCer analogues that induce a biased Th1/Th2 response are highly awaited. In this context, we report the synthesis and in vitro evaluation of ?-Gal-D-xylo-Cer and two ?-Gal-L-lyxo-Cer analogues, one with the natural acyl chain, the other with a truncated chain.
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Published date: 14 July 2008
Keywords:
?-galactosylceramide, cytokines, epimers, glycolipids, NKT cells
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Local EPrints ID: 148347
URI: http://eprints.soton.ac.uk/id/eprint/148347
ISSN: 1860-7179
PURE UUID: 84182c2c-f3b4-4e7f-9659-40cda0b50548
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Date deposited: 27 Apr 2010 15:48
Last modified: 14 Mar 2024 02:45
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Contributors
Author:
Matthias Trappeniers
Author:
Stijn Goormans
Author:
Katrien Van Beneden
Author:
Tine Decruy
Author:
Joern M. Werner
Author:
Dirk Elewaut
Author:
Serge Van Calenbergh
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