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Synthesis and in vitro evaluation of ?-GalCer epimers

Record type: Article

?-GalCer (also known as KRN7000) is an immunomodulatory glycolipid that is known to potently activate invariant natural killer T (NKT) cells upon CD1d-mediated stimulation. Because Th1 and Th2 cytokines, which are released after ?-GalCer presentation, antagonize each other's effects, ?-GalCer analogues that induce a biased Th1/Th2 response are highly awaited. In this context, we report the synthesis and in vitro evaluation of ?-Gal-D-xylo-Cer and two ?-Gal-L-lyxo-Cer analogues, one with the natural acyl chain, the other with a truncated chain.

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Trappeniers, Matthias, Goormans, Stijn, Van Beneden, Katrien, Decruy, Tine, Linclau, Bruno, Al-Shamkhani, Aymen, Elliott, Tim, Ottensmeier, Christian, Werner, Joern M., Elewaut, Dirk and Van Calenbergh, Serge (2008) Synthesis and in vitro evaluation of ?-GalCer epimers ChemMedChem, 3, (7), pp. 1061-1070. (doi:10.1002/cmdc.200800021).

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Published date: 14 July 2008
Keywords: ?-galactosylceramide, cytokines, epimers, glycolipids, NKT cells


Local EPrints ID: 148347
ISSN: 1860-7179
PURE UUID: 84182c2c-f3b4-4e7f-9659-40cda0b50548
ORCID for Bruno Linclau: ORCID iD
ORCID for Tim Elliott: ORCID iD

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Date deposited: 27 Apr 2010 15:48
Last modified: 18 Jul 2017 19:32

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Author: Matthias Trappeniers
Author: Stijn Goormans
Author: Katrien Van Beneden
Author: Tine Decruy
Author: Bruno Linclau ORCID iD
Author: Tim Elliott ORCID iD
Author: Joern M. Werner
Author: Dirk Elewaut
Author: Serge Van Calenbergh

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