Trappeniers, Matthias, Goormans, Stijn, Van Beneden, Katrien, Decruy, Tine, Linclau, Bruno, Al-Shamkhani, Aymen, Elliott, Tim, Ottensmeier, Christian, Werner, Joern M., Elewaut, Dirk and Van Calenbergh, Serge
Synthesis and in vitro evaluation of ?-GalCer epimers
ChemMedChem, 3, (7), . (doi:10.1002/cmdc.200800021).
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?-GalCer (also known as KRN7000) is an immunomodulatory glycolipid that is known to potently activate invariant natural killer T (NKT) cells upon CD1d-mediated stimulation. Because Th1 and Th2 cytokines, which are released after ?-GalCer presentation, antagonize each other's effects, ?-GalCer analogues that induce a biased Th1/Th2 response are highly awaited. In this context, we report the synthesis and in vitro evaluation of ?-Gal-D-xylo-Cer and two ?-Gal-L-lyxo-Cer analogues, one with the natural acyl chain, the other with a truncated chain.
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