The University of Southampton
University of Southampton Institutional Repository

Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder

Thapar, Anita, Langley, Kate, Fowler, Tom, Rice, Frances, Turic, Darko, Whittinger, Naureen, Aggleton, John, Van den Bree, Marianne, Owen, Michael and O'Donovan, Michael (2005) Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder Archives of General Psychiatry, 62, (11), pp. 1275-1278.

Record type: Article

Abstract

Context: Early-onset antisocial behavior accompanied by attention-deficit/hyperactivity disorder is a clinically severe variant of antisocial behavior that is associated with a particularly poor outcome. Identifying early predictors is thus important. Genetic and prenatal environmental risk factors and prefrontal cortical function are thought to contribute. Recent evidence suggests that prefrontal cortical function is influenced by a valine/methionine variant in the catechol O-methyltransferase (COMT) gene.

Objective: To test the a priori hypothesis that this genetic variant predicts early-onset antisocial behavior in a high-risk sample and further examine the effects of birth weight, an environmentally influenced index of prenatal adversity previously linked to childhood disruptive behaviors and genotype x birth weight interaction.

Design, Setting, and Participants: A family-based genetic study was undertaken between 1997 and 2003. Participants were prospectively recruited from child and adolescent psychiatry and child health clinics in the United Kingdom and included 240 clinic children who met diagnostic criteria for attention-deficit/hyperactivity disorder or hyperkinetic disorder. Participants underwent comprehensive standardized assessments including measures of antisocial behavior and IQ.

Main Outcome Measure: DSM-IV symptoms of childhood-onset conduct disorder rated by trained interviewers using a standard diagnostic interview.

Results: The results show main effects of the COMT gene variant (P = .002), birth weight (P = .002), and a significant gene x environment (COMT x birth weight) interaction (P = .006).

Conclusions: Early-onset antisocial behavior in a high-risk clinical group is predicted by a specific COMT gene variant previously linked with prefrontal cortical function and birth weight, and those possessing the val/val genotype are more susceptible to the adverse effects of prenatal risk as indexed by lower birth weight.

Full text not available from this repository.

More information

Published date: November 2005

Identifiers

Local EPrints ID: 148353
URI: http://eprints.soton.ac.uk/id/eprint/148353
ISSN: 0003-990X
PURE UUID: 9ac177c1-1eb5-42c0-9f58-1517edade7da

Catalogue record

Date deposited: 28 Jun 2010 08:40
Last modified: 18 Jul 2017 19:32

Export record

Contributors

Author: Anita Thapar
Author: Kate Langley
Author: Tom Fowler
Author: Frances Rice
Author: Darko Turic
Author: Naureen Whittinger
Author: John Aggleton
Author: Marianne Van den Bree
Author: Michael Owen
Author: Michael O'Donovan

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×