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No support for association between the dopamine transporter (DAT1) gene and ADHD

No support for association between the dopamine transporter (DAT1) gene and ADHD
No support for association between the dopamine transporter (DAT1) gene and ADHD
Several groups have reported an association between the 10-repeat allele of a dopamine transporter (DAT1) 3UTR VNTR variant and ADHD but the finding has not been universally observed. An association between DAT1 genotype and stimulant medication response has also been reported although again there are conflicting data. We tested the DAT1 3VNTR and three SNPs in the putative promoter region of DAT1 for association with ADHD in 263 parent-proband trios. Analyses of genotypes, alleles, and haplotypes were performed using family-based association methods. Case-control analysis of the VNTR in 263 cases and 287 controls was also conducted. In addition, we tested for association between the VNTR marker and stimulant medication response. Comparing allele 10 versus all other alleles combined, no significant association was found with ADHD, using FBAT analysis (2 = 0.1 (df 1), P = 0.9, (odds ratio (OR) = 1.0, 95% CI 0.8-1.2), and case-control analysis (2 = 0.12 (df 2), P = 0.91). No evidence of association with any of the SNPs in the promoter region was found. Haplotype analysis was also non-significant (2 = 3.93, (df 9) global P = 0.85). Finally, no association was found between the DAT 1 VNTR and response to stimulant medication (2 = 1.63 (df 3) P = 0.65). We conclude that the 3 VNTR and three additional promoter variants in DAT1 do not appear to be associated with ADHD, or response to stimulant mediation in our sample
dopamine transporter (DAT1), medication response, haplotype, attention deficit hyperactivity disorder (ADHD, promoter polymorphism
1552-4841
7-10
Langley, K.
ce8d5c40-3372-4746-a091-55f787db296f
Turic, D.
492e37c3-c13b-4c7e-a73f-076525e9e3f1
Peirce, T.R.
2d23e642-8a08-41fb-b454-d6624671d3b1
Mills, S.
e62e70ad-5e1d-4e51-a57e-028a6d412df2
Van Den Bree, M.B.
9dd993e3-f258-4182-bf30-10f2c37421a3
Owen, M.J.
e6b69d43-8f87-40b8-a089-01bbe02ef7b8
O'Donovan, M.C.
07541263-71ea-4d7e-ba4e-2ced1268be5a
Thapar, A.
792558b3-01ec-4ccf-83c6-9f408aa3b601
Langley, K.
ce8d5c40-3372-4746-a091-55f787db296f
Turic, D.
492e37c3-c13b-4c7e-a73f-076525e9e3f1
Peirce, T.R.
2d23e642-8a08-41fb-b454-d6624671d3b1
Mills, S.
e62e70ad-5e1d-4e51-a57e-028a6d412df2
Van Den Bree, M.B.
9dd993e3-f258-4182-bf30-10f2c37421a3
Owen, M.J.
e6b69d43-8f87-40b8-a089-01bbe02ef7b8
O'Donovan, M.C.
07541263-71ea-4d7e-ba4e-2ced1268be5a
Thapar, A.
792558b3-01ec-4ccf-83c6-9f408aa3b601

Langley, K., Turic, D., Peirce, T.R., Mills, S., Van Den Bree, M.B., Owen, M.J., O'Donovan, M.C. and Thapar, A. (2005) No support for association between the dopamine transporter (DAT1) gene and ADHD. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 139B (1), 7-10. (doi:10.1002/ajmg.b.30206).

Record type: Article

Abstract

Several groups have reported an association between the 10-repeat allele of a dopamine transporter (DAT1) 3UTR VNTR variant and ADHD but the finding has not been universally observed. An association between DAT1 genotype and stimulant medication response has also been reported although again there are conflicting data. We tested the DAT1 3VNTR and three SNPs in the putative promoter region of DAT1 for association with ADHD in 263 parent-proband trios. Analyses of genotypes, alleles, and haplotypes were performed using family-based association methods. Case-control analysis of the VNTR in 263 cases and 287 controls was also conducted. In addition, we tested for association between the VNTR marker and stimulant medication response. Comparing allele 10 versus all other alleles combined, no significant association was found with ADHD, using FBAT analysis (2 = 0.1 (df 1), P = 0.9, (odds ratio (OR) = 1.0, 95% CI 0.8-1.2), and case-control analysis (2 = 0.12 (df 2), P = 0.91). No evidence of association with any of the SNPs in the promoter region was found. Haplotype analysis was also non-significant (2 = 3.93, (df 9) global P = 0.85). Finally, no association was found between the DAT 1 VNTR and response to stimulant medication (2 = 1.63 (df 3) P = 0.65). We conclude that the 3 VNTR and three additional promoter variants in DAT1 do not appear to be associated with ADHD, or response to stimulant mediation in our sample

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More information

Published date: November 2005
Keywords: dopamine transporter (DAT1), medication response, haplotype, attention deficit hyperactivity disorder (ADHD, promoter polymorphism

Identifiers

Local EPrints ID: 148357
URI: http://eprints.soton.ac.uk/id/eprint/148357
ISSN: 1552-4841
PURE UUID: feace48a-0bcc-486e-811f-63af833a2065

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Date deposited: 29 Jun 2010 10:45
Last modified: 14 Mar 2024 01:02

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Contributors

Author: K. Langley
Author: D. Turic
Author: T.R. Peirce
Author: S. Mills
Author: M.B. Van Den Bree
Author: M.J. Owen
Author: M.C. O'Donovan
Author: A. Thapar

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