The University of Southampton
University of Southampton Institutional Repository

No support for association between the dopamine transporter (DAT1) gene and ADHD

Langley, K., Turic, D., Peirce, T.R., Mills, S., Van Den Bree, M.B., Owen, M.J., O'Donovan, M.C. and Thapar, A. (2005) No support for association between the dopamine transporter (DAT1) gene and ADHD American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 139B, (1), pp. 7-10. (doi:10.1002/ajmg.b.30206).

Record type: Article


Several groups have reported an association between the 10-repeat allele of a dopamine transporter (DAT1) 3UTR VNTR variant and ADHD but the finding has not been universally observed. An association between DAT1 genotype and stimulant medication response has also been reported although again there are conflicting data. We tested the DAT1 3VNTR and three SNPs in the putative promoter region of DAT1 for association with ADHD in 263 parent-proband trios. Analyses of genotypes, alleles, and haplotypes were performed using family-based association methods. Case-control analysis of the VNTR in 263 cases and 287 controls was also conducted. In addition, we tested for association between the VNTR marker and stimulant medication response. Comparing allele 10 versus all other alleles combined, no significant association was found with ADHD, using FBAT analysis (2 = 0.1 (df 1), P = 0.9, (odds ratio (OR) = 1.0, 95% CI 0.8-1.2), and case-control analysis (2 = 0.12 (df 2), P = 0.91). No evidence of association with any of the SNPs in the promoter region was found. Haplotype analysis was also non-significant (2 = 3.93, (df 9) global P = 0.85). Finally, no association was found between the DAT 1 VNTR and response to stimulant medication (2 = 1.63 (df 3) P = 0.65). We conclude that the 3 VNTR and three additional promoter variants in DAT1 do not appear to be associated with ADHD, or response to stimulant mediation in our sample

Full text not available from this repository.

More information

Published date: November 2005
Keywords: dopamine transporter (DAT1), medication response, haplotype, attention deficit hyperactivity disorder (ADHD, promoter polymorphism


Local EPrints ID: 148357
ISSN: 1552-4841
PURE UUID: feace48a-0bcc-486e-811f-63af833a2065

Catalogue record

Date deposited: 29 Jun 2010 10:45
Last modified: 18 Jul 2017 19:32

Export record



Author: K. Langley
Author: D. Turic
Author: T.R. Peirce
Author: S. Mills
Author: M.B. Van Den Bree
Author: M.J. Owen
Author: M.C. O'Donovan
Author: A. Thapar

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.