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A family based study implicates solute carrier family 1–member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder

Record type: Article

The glutamatergic system, the major excitatory neurotransmitter system in the central nervous system (CNS) has been proposed as contributing a possible role in the etiology of attention deficit hyperactivity disorder (ADHD). This is based upon observations from animal, neuroimaging, neuroanatomical and neuropsychological studies. Genes related to glutamate function are therefore good functional candidates for this disorder. The SLC1A3 (Solute Carrier Family 1, member 3) gene encodes a glial glutamate transporter which maps to chromosome 5p12, a region of linkage that coincides in two published ADHD genome scans so far. SLC1A3 is thus both a functional and positional candidate gene for ADHD

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Citation

Turic, Darko, Langley, Kate, Williams, Hywel, Norton, Nadine, Williams, Nigel M., Moskvina, Valentina, Van den Bree, Marianne B., Owen, Michael J., Thapar, Anita and O'Donovan, Michael C. (2005) A family based study implicates solute carrier family 1–member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder Biological Psychiatry, 57, (11), pp. 1461-1466. (doi:10.1016/j.biopsych.2005.03.025).

More information

Published date: June 2005
Keywords: SLC1A3, glutamate function, polymorphisms, haplotype, attention deficit hyperactivity disorder (ADHD)

Identifiers

Local EPrints ID: 148359
URI: http://eprints.soton.ac.uk/id/eprint/148359
ISSN: 0006-3223
PURE UUID: 8d9aa8d7-6e6d-4c11-95fb-521a05b4be0d

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Date deposited: 29 Jun 2010 10:40
Last modified: 18 Jul 2017 19:32

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Contributors

Author: Darko Turic
Author: Kate Langley
Author: Hywel Williams
Author: Nadine Norton
Author: Nigel M. Williams
Author: Valentina Moskvina
Author: Marianne B. Van den Bree
Author: Michael J. Owen
Author: Anita Thapar
Author: Michael C. O'Donovan

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