Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD
Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD
We have followed up the extensive replicated evidence that the dopamine DRD4 receptor is involved in the aetiology of ADHD by undertaking direct analysis of genes encoding other proteins in this effector system. We prioritised the genes encoding G protein subunits GT2, Go, GZ as these have been shown to transduce the effects of ligand binding at DRD4. We screened the exons of all three genes for sequence variation in 28 unrelated subjects with ADHD and identified 13 novel polymorphisms. All were tested for possible association with ADHD using a combination of pooled and individual genotyping. The results of our study do not suggest that polymorphisms in these genes contribute to susceptibility to ADHD
68-72
Turic, D.
492e37c3-c13b-4c7e-a73f-076525e9e3f1
Langley, K.
ce8d5c40-3372-4746-a091-55f787db296f
Kirov, G.
cf77856b-5de4-4035-807b-8f3b3d32832a
Owen, M.J.
e6b69d43-8f87-40b8-a089-01bbe02ef7b8
Thapar, A.
792558b3-01ec-4ccf-83c6-9f408aa3b601
O'Donovan, M.C.
07541263-71ea-4d7e-ba4e-2ced1268be5a
May 2004
Turic, D.
492e37c3-c13b-4c7e-a73f-076525e9e3f1
Langley, K.
ce8d5c40-3372-4746-a091-55f787db296f
Kirov, G.
cf77856b-5de4-4035-807b-8f3b3d32832a
Owen, M.J.
e6b69d43-8f87-40b8-a089-01bbe02ef7b8
Thapar, A.
792558b3-01ec-4ccf-83c6-9f408aa3b601
O'Donovan, M.C.
07541263-71ea-4d7e-ba4e-2ced1268be5a
Turic, D., Langley, K., Kirov, G., Owen, M.J., Thapar, A. and O'Donovan, M.C.
(2004)
Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD.
American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 127B (1), .
(doi:10.1002/ajmg.b.20173).
Abstract
We have followed up the extensive replicated evidence that the dopamine DRD4 receptor is involved in the aetiology of ADHD by undertaking direct analysis of genes encoding other proteins in this effector system. We prioritised the genes encoding G protein subunits GT2, Go, GZ as these have been shown to transduce the effects of ligand binding at DRD4. We screened the exons of all three genes for sequence variation in 28 unrelated subjects with ADHD and identified 13 novel polymorphisms. All were tested for possible association with ADHD using a combination of pooled and individual genotyping. The results of our study do not suggest that polymorphisms in these genes contribute to susceptibility to ADHD
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Published date: May 2004
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Local EPrints ID: 148373
URI: http://eprints.soton.ac.uk/id/eprint/148373
ISSN: 1552-4841
PURE UUID: b01a0c72-17ba-4e26-a142-04ffb9be7be0
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Date deposited: 05 Jul 2010 13:26
Last modified: 14 Mar 2024 01:02
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Author:
D. Turic
Author:
K. Langley
Author:
G. Kirov
Author:
M.J. Owen
Author:
A. Thapar
Author:
M.C. O'Donovan
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