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A functional polymorphism in the succinate-semialdehyde dehydrogenase (aldehyde dehydrogenase 5 family, member A1) gene is associated with cognitive ability

A functional polymorphism in the succinate-semialdehyde dehydrogenase (aldehyde dehydrogenase 5 family, member A1) gene is associated with cognitive ability
A functional polymorphism in the succinate-semialdehyde dehydrogenase (aldehyde dehydrogenase 5 family, member A1) gene is associated with cognitive ability
Succinate-semialdehyde dehydrogenase (SSADH) deficiency is a rare cause of learning disability. We have investigated SSADH to assess its contribution to cognitive ability in the general population in both case–control- and family-based analyses. Sequence analysis of SSADH revealed four changes affecting the encoded protein, only one of which had a minor allele whose frequency is even moderately common. We genotyped this functional polymorphism in 197 high-IQ cases, 201 average-IQ controls and 196 parent high-IQ offspring trios. The minor allele was significantly less frequent in high-IQ cases and was significantly less frequently transmitted by parents to high-IQ subjects than chance expectation. A previous study has shown that the minor allele encodes a lower activity enzyme than the major allele. These data suggest that higher SSADH activity is associated with higher intelligence across the general population. The effect is small, with each allele having an effect size translating to about 1.5 IQ points
succinate-semialdehyde dehydrogenase (SSADH), functional polymorphism, QTL, cognition, intelligence
1359-4184
582-586
Plomin, R.
88092461-3f96-4112-af35-b8e772ee9bc9
Turic, D.M.
0f283a69-4e75-43b4-90ac-0d221ff797d4
Hill, L.
d4e10721-0219-44f3-860f-9501b9ac9681
Turic, D .
f957ee33-b180-439b-80b1-32c064e25082
Stephens, M.
8114316d-c6ec-4a56-9fdc-3c1d9f27e0de
Williams, J.
2ab33bc3-4988-493b-9cd5-ac68d28385cb
Owen, M.J.
e6b69d43-8f87-40b8-a089-01bbe02ef7b8
O'Donovan, M.C.
07541263-71ea-4d7e-ba4e-2ced1268be5a
Plomin, R.
88092461-3f96-4112-af35-b8e772ee9bc9
Turic, D.M.
0f283a69-4e75-43b4-90ac-0d221ff797d4
Hill, L.
d4e10721-0219-44f3-860f-9501b9ac9681
Turic, D .
f957ee33-b180-439b-80b1-32c064e25082
Stephens, M.
8114316d-c6ec-4a56-9fdc-3c1d9f27e0de
Williams, J.
2ab33bc3-4988-493b-9cd5-ac68d28385cb
Owen, M.J.
e6b69d43-8f87-40b8-a089-01bbe02ef7b8
O'Donovan, M.C.
07541263-71ea-4d7e-ba4e-2ced1268be5a

Plomin, R., Turic, D.M., Hill, L., Turic, D ., Stephens, M., Williams, J., Owen, M.J. and O'Donovan, M.C. (2004) A functional polymorphism in the succinate-semialdehyde dehydrogenase (aldehyde dehydrogenase 5 family, member A1) gene is associated with cognitive ability. Molecular Psychiatry, 9 (6), 582-586. (doi:10.1038/sj.mp.4001441).

Record type: Article

Abstract

Succinate-semialdehyde dehydrogenase (SSADH) deficiency is a rare cause of learning disability. We have investigated SSADH to assess its contribution to cognitive ability in the general population in both case–control- and family-based analyses. Sequence analysis of SSADH revealed four changes affecting the encoded protein, only one of which had a minor allele whose frequency is even moderately common. We genotyped this functional polymorphism in 197 high-IQ cases, 201 average-IQ controls and 196 parent high-IQ offspring trios. The minor allele was significantly less frequent in high-IQ cases and was significantly less frequently transmitted by parents to high-IQ subjects than chance expectation. A previous study has shown that the minor allele encodes a lower activity enzyme than the major allele. These data suggest that higher SSADH activity is associated with higher intelligence across the general population. The effect is small, with each allele having an effect size translating to about 1.5 IQ points

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More information

Published date: February 2004
Keywords: succinate-semialdehyde dehydrogenase (SSADH), functional polymorphism, QTL, cognition, intelligence

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Local EPrints ID: 148375
URI: http://eprints.soton.ac.uk/id/eprint/148375
ISSN: 1359-4184
PURE UUID: f7f14f3a-b48f-4178-b0b3-10808fee9e6a

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Date deposited: 05 Jul 2010 13:15
Last modified: 14 Mar 2024 01:02

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Contributors

Author: R. Plomin
Author: D.M. Turic
Author: L. Hill
Author: D . Turic
Author: M. Stephens
Author: J. Williams
Author: M.J. Owen
Author: M.C. O'Donovan

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