Mills, Sophie, Langley, Kate, Van den Bree, Marianne, Street, Eddy, Turic, Darko, Owen, Michael J., O'Donovan, Michael C. and Thapar, Anita
No evidence of association between Catechol-O-Methyltransferase (COMT) Val(158)Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study
BMC Psychiatry, 4, (1), . (doi:10.1186/1471-244X-4-15).
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Background: Several studies have suggested an association between the functional Val158Met
polymorphism in the Catechol-O-Methyltransferase (COMT) gene and neurocognitive performance.
Two studies showed that subjects with the low activity Met allele performed better on the
Wisconsin Card Sorting Test (WCST) and another study found an effect on processing speed and
Methods: We set out to examine the association between the Val158Met polymorphism and
performance on neurocognitive tasks including those tapping working memory, attention and
speed, impulsiveness and response inhibition in a sample of 124 children with ADHD. Task
performance for each genotypic group was compared using analysis of variance.
Results: There was no evidence of association with performance on any of the neurocognitive
Conclusions: We conclude that Val158Met COMT genotype is not associated with neurocognitive
performance in our sample.
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