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No evidence of association between Catechol-O-Methyltransferase (COMT) Val(158)Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study

Record type: Article

Background: Several studies have suggested an association between the functional Val158Met
polymorphism in the Catechol-O-Methyltransferase (COMT) gene and neurocognitive performance.
Two studies showed that subjects with the low activity Met allele performed better on the
Wisconsin Card Sorting Test (WCST) and another study found an effect on processing speed and
attention.

Methods: We set out to examine the association between the Val158Met polymorphism and
performance on neurocognitive tasks including those tapping working memory, attention and
speed, impulsiveness and response inhibition in a sample of 124 children with ADHD. Task
performance for each genotypic group was compared using analysis of variance.

Results: There was no evidence of association with performance on any of the neurocognitive
tasks.

Conclusions: We conclude that Val158Met COMT genotype is not associated with neurocognitive
performance in our sample.

Full text not available from this repository.

Citation

Mills, Sophie, Langley, Kate, Van den Bree, Marianne, Street, Eddy, Turic, Darko, Owen, Michael J., O'Donovan, Michael C. and Thapar, Anita (2004) No evidence of association between Catechol-O-Methyltransferase (COMT) Val(158)Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study BMC Psychiatry, 4, (1), pp. 1-5. (doi:10.1186/1471-244X-4-15).

More information

Published date: 7 June 2004

Identifiers

Local EPrints ID: 148433
URI: http://eprints.soton.ac.uk/id/eprint/148433
ISSN: 0893-133X
PURE UUID: b21893fe-d03f-44b3-80ea-eff0c5eb1c03

Catalogue record

Date deposited: 05 Jul 2010 12:01
Last modified: 18 Jul 2017 19:32

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Contributors

Author: Sophie Mills
Author: Kate Langley
Author: Marianne Van den Bree
Author: Eddy Street
Author: Darko Turic
Author: Michael J. Owen
Author: Michael C. O'Donovan
Author: Anita Thapar

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