No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.

Payton, Antony, Turic, D, Langley, Kate, Mills, Sophie, Lawson, Deborah C., Van den Bree, Marianne, Owen, Michael J., O'Donovan, Michael Cc, Ollier, William, Worthington, Jane and Thapar, Anita (2003) No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder. Psychiatric Genetics, 13 (3), 183-5.

Abstract

OBJECTIVES: There has been a recent resurgence in interest in the role of autoimmunity in childhood neuropsychiatric disorders. Significant association between HLA-DRB1 and attention deficit hyperactivity disorder (ADHD) in a case-control study of 31 subjects has been reported but there have been no other published studies following up these results. We attempted to replicate these findings. METHODS: In a well-characterized sample of 173 children with ADHD, using a fully automated sequence-specific oligonucleotide method for HLA genotyping, association between ADHD and HLA-DRB1 was tested for using the Transmission Disequilibrium Test and case-control analysis. RESULTS: Transmission Disequilibrium Test analysis yielded a chi-square of 10.694 with a simulated global P value of 0.1641 for the full sample, and a chi-square value of 11.307 with a simulated global P value of 0.1323 for the complete trios only. CONCLUSION: There was no evidence of association of HLA-DRB1 and ADHD.

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