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No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.

No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.
No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.
OBJECTIVES: There has been a recent resurgence in interest in the role of autoimmunity in childhood neuropsychiatric disorders. Significant association between HLA-DRB1 and attention deficit hyperactivity disorder (ADHD) in a case-control study of 31 subjects has been reported but there have been no other published studies following up these results. We attempted to replicate these findings. METHODS: In a well-characterized sample of 173 children with ADHD, using a fully automated sequence-specific oligonucleotide method for HLA genotyping, association between ADHD and HLA-DRB1 was tested for using the Transmission Disequilibrium Test and case-control analysis. RESULTS: Transmission Disequilibrium Test analysis yielded a chi-square of 10.694 with a simulated global P value of 0.1641 for the full sample, and a chi-square value of 11.307 with a simulated global P value of 0.1323 for the complete trios only. CONCLUSION: There was no evidence of association of HLA-DRB1 and ADHD.
0955-8829
183-5
Payton, Antony
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Turic, D
af473e34-6d9d-47a9-af16-041fc3361b7e
Langley, Kate
ed24ec9b-422b-4b00-885c-6c1eba2d1089
Mills, Sophie
45637a28-f819-4c7a-91a5-24b171851dea
Lawson, Deborah C.
c690cd38-08ca-4add-aae5-2f2fabedc793
Van den Bree, Marianne
b838bc38-ef0d-4711-bcec-9359e30d68a8
Owen, Michael J.
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O'Donovan, Michael Cc
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Ollier, William
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Worthington, Jane
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Thapar, Anita
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Payton, Antony
eedef58d-bd8b-4adb-b8d1-6b444bbf66ab
Turic, D
af473e34-6d9d-47a9-af16-041fc3361b7e
Langley, Kate
ed24ec9b-422b-4b00-885c-6c1eba2d1089
Mills, Sophie
45637a28-f819-4c7a-91a5-24b171851dea
Lawson, Deborah C.
c690cd38-08ca-4add-aae5-2f2fabedc793
Van den Bree, Marianne
b838bc38-ef0d-4711-bcec-9359e30d68a8
Owen, Michael J.
0e3a340c-b3a3-4631-94f6-b3f50c0d50b1
O'Donovan, Michael Cc
2a5db00d-5576-4868-bc88-ba4505c21494
Ollier, William
36ca1aa8-617b-45d6-b972-b345f718129f
Worthington, Jane
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Thapar, Anita
224b4dc1-a6ee-455a-95f9-b9a716606aa6

Payton, Antony, Turic, D, Langley, Kate, Mills, Sophie, Lawson, Deborah C., Van den Bree, Marianne, Owen, Michael J., O'Donovan, Michael Cc, Ollier, William, Worthington, Jane and Thapar, Anita (2003) No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder. Psychiatric Genetics, 13 (3), 183-5.

Record type: Article

Abstract

OBJECTIVES: There has been a recent resurgence in interest in the role of autoimmunity in childhood neuropsychiatric disorders. Significant association between HLA-DRB1 and attention deficit hyperactivity disorder (ADHD) in a case-control study of 31 subjects has been reported but there have been no other published studies following up these results. We attempted to replicate these findings. METHODS: In a well-characterized sample of 173 children with ADHD, using a fully automated sequence-specific oligonucleotide method for HLA genotyping, association between ADHD and HLA-DRB1 was tested for using the Transmission Disequilibrium Test and case-control analysis. RESULTS: Transmission Disequilibrium Test analysis yielded a chi-square of 10.694 with a simulated global P value of 0.1641 for the full sample, and a chi-square value of 11.307 with a simulated global P value of 0.1323 for the complete trios only. CONCLUSION: There was no evidence of association of HLA-DRB1 and ADHD.

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Published date: September 2003

Identifiers

Local EPrints ID: 148435
URI: http://eprints.soton.ac.uk/id/eprint/148435
ISSN: 0955-8829
PURE UUID: 8b2d04d8-11e7-4a39-9b69-cc62921da674

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Date deposited: 08 Jul 2010 14:09
Last modified: 08 Jan 2022 02:27

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Contributors

Author: Antony Payton
Author: D Turic
Author: Kate Langley
Author: Sophie Mills
Author: Deborah C. Lawson
Author: Marianne Van den Bree
Author: Michael J. Owen
Author: Michael Cc O'Donovan
Author: William Ollier
Author: Jane Worthington
Author: Anita Thapar

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