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EEG and cerebral blood flow in newborns during quiet sleep

EEG and cerebral blood flow in newborns during quiet sleep
EEG and cerebral blood flow in newborns during quiet sleep
Cerebral blood flow (CBF) alterations in the newborns (NB) can lead to brain damage by a
decrease in the supply of oxygen and glucose. Aiming at contributing to an understanding of the
mechanisms involved, the association between the EEG (right front-temporal derivation) and Doppler
velocimetry of the middle cerebral artery from term NB has been investigated. These signals were
simultaneously collected from 20 NB and then epochs during quiet sleep (Tracé Alternant, TA, and
High Voltage Slow, HVS) were selected. EEG power in theta band (Pthet, 4-8 Hz), was estimated each
second. For CBF, obtained from velocimetry, the average velocity (V) was extracted for each heart
cycle. To investigate the association in the time (cross correlation function - CCF) and frequency
domains (magnitude square coherence - MSC) signal processing techniques were developed that can
deal with interruptions in the data (missing samples). During TA, the CCF between Pthet and V resulted in a maximum value around -5 s (Pthet leading V) in 85% of the NBs with p? 0.05(significance was tested by Monte Carlo simulations). The maximum of the MSC occurred around 0.10
Hz in 92 % of the NB (p? 0.05). These findings indicate association between the neuronal activity and CBF during TA. The high coherence could be interpreted as TA.
cerebral blood flow control, neonatal eeg, coherence, cross-correlation, autoregulation
1456-7857
261-268
Botero Rosas, D.A.
f9514b32-4b10-4e0d-a4d9-6ac60eaf5a85
Infantosi, A.F.C.
35b46937-63c6-421a-ab26-dc950c194bbd
Simpson, D.M.
53674880-f381-4cc9-8505-6a97eeac3c2a
Maldonado Arango, M.I.
b7819afa-d76a-434b-a201-1036e6d4383a
Botero Rosas, D.A.
f9514b32-4b10-4e0d-a4d9-6ac60eaf5a85
Infantosi, A.F.C.
35b46937-63c6-421a-ab26-dc950c194bbd
Simpson, D.M.
53674880-f381-4cc9-8505-6a97eeac3c2a
Maldonado Arango, M.I.
b7819afa-d76a-434b-a201-1036e6d4383a

Botero Rosas, D.A., Infantosi, A.F.C., Simpson, D.M. and Maldonado Arango, M.I. (2008) EEG and cerebral blood flow in newborns during quiet sleep. International Journal of Bioelectromagnetism, 10 (4), 261-268.

Record type: Article

Abstract

Cerebral blood flow (CBF) alterations in the newborns (NB) can lead to brain damage by a
decrease in the supply of oxygen and glucose. Aiming at contributing to an understanding of the
mechanisms involved, the association between the EEG (right front-temporal derivation) and Doppler
velocimetry of the middle cerebral artery from term NB has been investigated. These signals were
simultaneously collected from 20 NB and then epochs during quiet sleep (Tracé Alternant, TA, and
High Voltage Slow, HVS) were selected. EEG power in theta band (Pthet, 4-8 Hz), was estimated each
second. For CBF, obtained from velocimetry, the average velocity (V) was extracted for each heart
cycle. To investigate the association in the time (cross correlation function - CCF) and frequency
domains (magnitude square coherence - MSC) signal processing techniques were developed that can
deal with interruptions in the data (missing samples). During TA, the CCF between Pthet and V resulted in a maximum value around -5 s (Pthet leading V) in 85% of the NBs with p? 0.05(significance was tested by Monte Carlo simulations). The maximum of the MSC occurred around 0.10
Hz in 92 % of the NB (p? 0.05). These findings indicate association between the neuronal activity and CBF during TA. The high coherence could be interpreted as TA.

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Published date: 2008
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Keywords: cerebral blood flow control, neonatal eeg, coherence, cross-correlation, autoregulation

Identifiers

Local EPrints ID: 148465
URI: https://eprints.soton.ac.uk/id/eprint/148465
ISSN: 1456-7857
PURE UUID: 3bb8f1cd-44d0-43e4-8bf7-95d1cf3fbb55

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Date deposited: 28 Apr 2010 08:55
Last modified: 18 Jul 2017 19:31

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