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Total synthesis of annonaceous acetogenins belonging to the non-adjacent Bis-THF and non-adjacent THF-THP sub-classes

Total synthesis of annonaceous acetogenins belonging to the non-adjacent Bis-THF and non-adjacent THF-THP sub-classes
Total synthesis of annonaceous acetogenins belonging to the non-adjacent Bis-THF and non-adjacent THF-THP sub-classes
The synthesis of the subgroups of acetogenins containing non-adjacent bis-THF and non-adjacent THF-THP core units is reviewed. Specifically, total syntheses of gigantecin, 4-deoxygigantecin, cis-sylvaticin, squamostatin-C, squamostatin-D, sylvaticin and mucocin are discussed.
annonaceous acetogenins, non-adjacent bis-THF, tetrahydrofuran, tetrahydropyran, asymmetric synthesis, 1, 2-diols, epoxides, cytotoxic natural products, anti-tumour
460-501
Spurr, Ian B.
fb87bcbc-46d2-4cb0-8240-ecdfaf013d1d
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Spurr, Ian B.
fb87bcbc-46d2-4cb0-8240-ecdfaf013d1d
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5

Spurr, Ian B. and Brown, Richard C.D. (2010) Total synthesis of annonaceous acetogenins belonging to the non-adjacent Bis-THF and non-adjacent THF-THP sub-classes. Molecules, 15 (1), 460-501. (doi:10.3390/molecules15010460).

Record type: Article

Abstract

The synthesis of the subgroups of acetogenins containing non-adjacent bis-THF and non-adjacent THF-THP core units is reviewed. Specifically, total syntheses of gigantecin, 4-deoxygigantecin, cis-sylvaticin, squamostatin-C, squamostatin-D, sylvaticin and mucocin are discussed.

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More information

Published date: 2010
Keywords: annonaceous acetogenins, non-adjacent bis-THF, tetrahydrofuran, tetrahydropyran, asymmetric synthesis, 1, 2-diols, epoxides, cytotoxic natural products, anti-tumour

Identifiers

Local EPrints ID: 148877
URI: http://eprints.soton.ac.uk/id/eprint/148877
PURE UUID: b7434b57-4a4e-4796-8520-272501e8aaea
ORCID for Richard C.D. Brown: ORCID iD orcid.org/0000-0003-0156-7087

Catalogue record

Date deposited: 29 Apr 2010 08:36
Last modified: 26 Nov 2019 01:59

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