Synthesis and applications of tert-alkoxysiloxane linkers in solid-phase chemistry
Synthesis and applications of tert-alkoxysiloxane linkers in solid-phase chemistry
Straightforward syntheses of two tert-alkoxysilyl chloride functionalised resins 3 and 31 that allow facile attachment of 1°, 2°, 3° alcohols and phenols to the solid-phase have been achieved. Resin 3 displayed useful loading levels (0.7 mmol/g), and it was stable to storage in activated form. Siloxanes from reaction of 3 with alcohols and phenols were compatible with a variety of reaction conditions commonly used in solid-phase synthesis.
299-311
Meloni, M.
3e2465dd-7326-406c-b2eb-1eca02968aa6
White, P.
7af189b9-069f-440f-bbef-78c56ae40bb6
Armour, D.
464a2727-1ceb-4da6-8a84-4471c94a282b
Brown, R.
21ce697a-7c3a-480e-919f-429a3d8550f5
8 January 2007
Meloni, M.
3e2465dd-7326-406c-b2eb-1eca02968aa6
White, P.
7af189b9-069f-440f-bbef-78c56ae40bb6
Armour, D.
464a2727-1ceb-4da6-8a84-4471c94a282b
Brown, R.
21ce697a-7c3a-480e-919f-429a3d8550f5
Meloni, M., White, P., Armour, D. and Brown, R.
(2007)
Synthesis and applications of tert-alkoxysiloxane linkers in solid-phase chemistry.
Tetrahedron, 63 (2), .
(doi:10.1016/J.Tet.2006.10.052).
Abstract
Straightforward syntheses of two tert-alkoxysilyl chloride functionalised resins 3 and 31 that allow facile attachment of 1°, 2°, 3° alcohols and phenols to the solid-phase have been achieved. Resin 3 displayed useful loading levels (0.7 mmol/g), and it was stable to storage in activated form. Siloxanes from reaction of 3 with alcohols and phenols were compatible with a variety of reaction conditions commonly used in solid-phase synthesis.
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Published date: 8 January 2007
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Local EPrints ID: 148929
URI: http://eprints.soton.ac.uk/id/eprint/148929
ISSN: 0040-4020
PURE UUID: 592f59b6-aee5-4cca-8de0-e7bab8f4a4fd
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Date deposited: 03 Jun 2010 13:51
Last modified: 14 Mar 2024 02:40
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Author:
M. Meloni
Author:
P. White
Author:
D. Armour
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