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Peptide antagonism as a mechanism for NK Cell activation

Record type: Article

Inhibition of natural killer (NK) cells is mediated by MHC class I receptors including the killer cell Ig-like receptor (KIR). We demonstrate that HLA-C binding peptides can function as altered peptide ligands for KIR and antagonize the inhibition mediated by KIR2DL2/KIR2DL3. Antagonistic peptides promote clustering of KIR at the interface of effector and target cells, but do not result in inhibition of NK cells. Our data show that, as for T cells, small changes in the peptide content of MHC class I can regulate NK cell activity.

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Citation

Fadda, Lena, Borhis, Gwenoline, Ahmed, Parvin, Cheent, Kuldeep, Pageon, Sophie V., Cazaly, Angelica, Stathopoulos, Stavros, Middleton, Derek, Mulder, Arend, Claas, Frans H.J., Elliott, Tim, Davis, Daniel M., Purbhoo, Marco A. and Khakoo, Salim I. (2010) Peptide antagonism as a mechanism for NK Cell activation Proceedings of the National Academy of Sciences, 107, (22), pp. 10160-10165. (doi:10.1073/pnas.0913745107). (PMID:20534579).

More information

Published date: 1 June 2010
Keywords: killer cell immunoglobulin-like receptors, mhc class I
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 148951
URI: http://eprints.soton.ac.uk/id/eprint/148951
ISSN: 0027-8424
PURE UUID: d8b22320-0f25-4a55-b254-21d6ff6f5e2e
ORCID for Tim Elliott: ORCID iD orcid.org/0000-0003-1097-0222

Catalogue record

Date deposited: 04 May 2010 15:49
Last modified: 18 Jul 2017 19:31

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Contributors

Author: Lena Fadda
Author: Gwenoline Borhis
Author: Parvin Ahmed
Author: Kuldeep Cheent
Author: Sophie V. Pageon
Author: Angelica Cazaly
Author: Stavros Stathopoulos
Author: Derek Middleton
Author: Arend Mulder
Author: Frans H.J. Claas
Author: Tim Elliott ORCID iD
Author: Daniel M. Davis
Author: Marco A. Purbhoo
Author: Salim I. Khakoo

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