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Peptide antagonism as a mechanism for NK Cell activation

Record type: Article

Inhibition of natural killer (NK) cells is mediated by MHC class I receptors including the killer cell Ig-like receptor (KIR). We demonstrate that HLA-C binding peptides can function as altered peptide ligands for KIR and antagonize the inhibition mediated by KIR2DL2/KIR2DL3. Antagonistic peptides promote clustering of KIR at the interface of effector and target cells, but do not result in inhibition of NK cells. Our data show that, as for T cells, small changes in the peptide content of MHC class I can regulate NK cell activity.

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Fadda, Lena, Borhis, Gwenoline, Ahmed, Parvin, Cheent, Kuldeep, Pageon, Sophie V., Cazaly, Angelica, Stathopoulos, Stavros, Middleton, Derek, Mulder, Arend, Claas, Frans H.J., Elliott, Tim, Davis, Daniel M., Purbhoo, Marco A. and Khakoo, Salim I. (2010) Peptide antagonism as a mechanism for NK Cell activation Proceedings of the National Academy of Sciences, 107, (22), pp. 10160-10165. (doi:10.1073/pnas.0913745107). (PMID:20534579).

More information

Published date: 1 June 2010
Keywords: killer cell immunoglobulin-like receptors, mhc class I
Organisations: Cancer Sciences


Local EPrints ID: 148951
ISSN: 0027-8424
PURE UUID: d8b22320-0f25-4a55-b254-21d6ff6f5e2e
ORCID for Tim Elliott: ORCID iD

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Date deposited: 04 May 2010 15:49
Last modified: 18 Jul 2017 19:31

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Author: Lena Fadda
Author: Gwenoline Borhis
Author: Parvin Ahmed
Author: Kuldeep Cheent
Author: Sophie V. Pageon
Author: Angelica Cazaly
Author: Stavros Stathopoulos
Author: Derek Middleton
Author: Arend Mulder
Author: Frans H.J. Claas
Author: Tim Elliott ORCID iD
Author: Daniel M. Davis
Author: Marco A. Purbhoo
Author: Salim I. Khakoo

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