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Peptide antagonism as a mechanism for NK Cell activation

Peptide antagonism as a mechanism for NK Cell activation
Peptide antagonism as a mechanism for NK Cell activation
Inhibition of natural killer (NK) cells is mediated by MHC class I receptors including the killer cell Ig-like receptor (KIR). We demonstrate that HLA-C binding peptides can function as altered peptide ligands for KIR and antagonize the inhibition mediated by KIR2DL2/KIR2DL3. Antagonistic peptides promote clustering of KIR at the interface of effector and target cells, but do not result in inhibition of NK cells. Our data show that, as for T cells, small changes in the peptide content of MHC class I can regulate NK cell activity.
killer cell immunoglobulin-like receptors, mhc class I
0027-8424
10160-10165
Fadda, Lena
aa39ca15-e356-4617-a1b9-4fa7d91e2bec
Borhis, Gwenoline
8a33db74-836f-4e0b-a42f-b0402f44fa8a
Ahmed, Parvin
77517b39-60b4-4c28-987c-75d70cc362ff
Cheent, Kuldeep
fc998259-3582-4bb3-ae11-58e418666bbc
Pageon, Sophie V.
bd5a2b84-4f7a-43a4-b07d-e176759cfb84
Cazaly, Angelica
944b91cc-ab19-463c-ad08-a6b04c6e628d
Stathopoulos, Stavros
432e3e44-6554-4a51-957d-9b572b5bf17a
Middleton, Derek
c0d031f7-d0db-426c-9049-a3a7248125cf
Mulder, Arend
caf04be4-7be4-4cec-9a7b-32638c7a3688
Claas, Frans H.J.
11a3dc77-f915-4086-b7f4-b8632f998cb3
Elliott, Tim
16670fa8-c2f9-477a-91df-7c9e5b453e0e
Davis, Daniel M.
fe125d3a-075a-44b0-9e8b-d84c6c2e2035
Purbhoo, Marco A.
990498b1-eb64-406b-875a-181e9ffd94df
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Fadda, Lena
aa39ca15-e356-4617-a1b9-4fa7d91e2bec
Borhis, Gwenoline
8a33db74-836f-4e0b-a42f-b0402f44fa8a
Ahmed, Parvin
77517b39-60b4-4c28-987c-75d70cc362ff
Cheent, Kuldeep
fc998259-3582-4bb3-ae11-58e418666bbc
Pageon, Sophie V.
bd5a2b84-4f7a-43a4-b07d-e176759cfb84
Cazaly, Angelica
944b91cc-ab19-463c-ad08-a6b04c6e628d
Stathopoulos, Stavros
432e3e44-6554-4a51-957d-9b572b5bf17a
Middleton, Derek
c0d031f7-d0db-426c-9049-a3a7248125cf
Mulder, Arend
caf04be4-7be4-4cec-9a7b-32638c7a3688
Claas, Frans H.J.
11a3dc77-f915-4086-b7f4-b8632f998cb3
Elliott, Tim
16670fa8-c2f9-477a-91df-7c9e5b453e0e
Davis, Daniel M.
fe125d3a-075a-44b0-9e8b-d84c6c2e2035
Purbhoo, Marco A.
990498b1-eb64-406b-875a-181e9ffd94df
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273

Fadda, Lena, Borhis, Gwenoline, Ahmed, Parvin, Cheent, Kuldeep, Pageon, Sophie V., Cazaly, Angelica, Stathopoulos, Stavros, Middleton, Derek, Mulder, Arend, Claas, Frans H.J., Elliott, Tim, Davis, Daniel M., Purbhoo, Marco A. and Khakoo, Salim I. (2010) Peptide antagonism as a mechanism for NK Cell activation Proceedings of the National Academy of Sciences, 107, (22), pp. 10160-10165. (doi:10.1073/pnas.0913745107). (PMID:20534579).

Record type: Article

Abstract

Inhibition of natural killer (NK) cells is mediated by MHC class I receptors including the killer cell Ig-like receptor (KIR). We demonstrate that HLA-C binding peptides can function as altered peptide ligands for KIR and antagonize the inhibition mediated by KIR2DL2/KIR2DL3. Antagonistic peptides promote clustering of KIR at the interface of effector and target cells, but do not result in inhibition of NK cells. Our data show that, as for T cells, small changes in the peptide content of MHC class I can regulate NK cell activity.

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More information

Published date: 1 June 2010
Keywords: killer cell immunoglobulin-like receptors, mhc class I
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 148951
URI: http://eprints.soton.ac.uk/id/eprint/148951
ISSN: 0027-8424
PURE UUID: d8b22320-0f25-4a55-b254-21d6ff6f5e2e
ORCID for Tim Elliott: ORCID iD orcid.org/0000-0003-1097-0222

Catalogue record

Date deposited: 04 May 2010 15:49
Last modified: 18 Jul 2017 19:31

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Contributors

Author: Lena Fadda
Author: Gwenoline Borhis
Author: Parvin Ahmed
Author: Kuldeep Cheent
Author: Sophie V. Pageon
Author: Angelica Cazaly
Author: Stavros Stathopoulos
Author: Derek Middleton
Author: Arend Mulder
Author: Frans H.J. Claas
Author: Tim Elliott ORCID iD
Author: Daniel M. Davis
Author: Marco A. Purbhoo
Author: Salim I. Khakoo

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