Risk factors for high cerebral blood flow velocity and death in kenyan children with sickle cell anaemia: role of haemoglobin oxygen saturation and febrile illness
Risk factors for high cerebral blood flow velocity and death in kenyan children with sickle cell anaemia: role of haemoglobin oxygen saturation and febrile illness
High cerebral blood flow velocity (CBFv) and low haemoglobin oxygen saturation (SpO2) predict neurological complications in sickle cell anaemia (SCA) but any association is unclear. In a cross-sectional study of 105 Kenyan children, mean CBFv was 120 ± 34·9 cm/s; 3 had conditional CBFv (170–199 cm/s) but none had abnormal CBFv (>200 cm/s). After adjustment for age and haematocrit, CBFv ?150 cm/s was predicted by SpO2 ? 95% and history of fever. Four years later, 10 children were lost to follow-up, none had suffered neurological events and 11/95 (12%) had died, predicted by history of fever but not low SpO2. Natural history of SCA in Africa may be different from North America and Europe.
sickle cell anaemia, africa, transcranial doppler ultrasound, mortality, cerebrovascular accidents
529-532
Makani, Julie
76a145a7-02fc-43ea-a1df-3a52d2004e48
Kirkham, Fenella J.
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Komba, Albert
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Ajala-Agbo, Tolulope
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Otieno, Godfrey
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Fegan, Gregory
665c804f-5687-40f3-b40c-ccd88540f7aa
Williams, Thomas N.
35087fc8-4ba4-4730-94cb-db91ff13d58b
Marsh, Kevin
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Newton, Charles R.
ea661613-9a2d-4e14-8d04-2d1c0804a321
27 March 2009
Makani, Julie
76a145a7-02fc-43ea-a1df-3a52d2004e48
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Komba, Albert
08307c5e-f7e3-4328-9521-6ed8017a026b
Ajala-Agbo, Tolulope
6dc15b97-0db8-4db6-b4b4-0e1224e225f2
Otieno, Godfrey
f59a7a12-fa11-4e46-81d0-00b581e19b7f
Fegan, Gregory
665c804f-5687-40f3-b40c-ccd88540f7aa
Williams, Thomas N.
35087fc8-4ba4-4730-94cb-db91ff13d58b
Marsh, Kevin
6da72983-5d59-4c53-ad4d-cfccd5da3dda
Newton, Charles R.
ea661613-9a2d-4e14-8d04-2d1c0804a321
Makani, Julie, Kirkham, Fenella J., Komba, Albert, Ajala-Agbo, Tolulope, Otieno, Godfrey, Fegan, Gregory, Williams, Thomas N., Marsh, Kevin and Newton, Charles R.
(2009)
Risk factors for high cerebral blood flow velocity and death in kenyan children with sickle cell anaemia: role of haemoglobin oxygen saturation and febrile illness.
British Journal of Haematology, 145 (4), .
(doi:10.1111/j.1365-2141.2009.07660.x).
Abstract
High cerebral blood flow velocity (CBFv) and low haemoglobin oxygen saturation (SpO2) predict neurological complications in sickle cell anaemia (SCA) but any association is unclear. In a cross-sectional study of 105 Kenyan children, mean CBFv was 120 ± 34·9 cm/s; 3 had conditional CBFv (170–199 cm/s) but none had abnormal CBFv (>200 cm/s). After adjustment for age and haematocrit, CBFv ?150 cm/s was predicted by SpO2 ? 95% and history of fever. Four years later, 10 children were lost to follow-up, none had suffered neurological events and 11/95 (12%) had died, predicted by history of fever but not low SpO2. Natural history of SCA in Africa may be different from North America and Europe.
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Published date: 27 March 2009
Keywords:
sickle cell anaemia, africa, transcranial doppler ultrasound, mortality, cerebrovascular accidents
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Local EPrints ID: 149057
URI: http://eprints.soton.ac.uk/id/eprint/149057
ISSN: 0007-1048
PURE UUID: d6d880cc-fb05-479e-a1bf-a69dd6c5a2f3
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Date deposited: 29 Apr 2010 14:52
Last modified: 14 Mar 2024 02:45
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Author:
Julie Makani
Author:
Albert Komba
Author:
Tolulope Ajala-Agbo
Author:
Godfrey Otieno
Author:
Gregory Fegan
Author:
Thomas N. Williams
Author:
Kevin Marsh
Author:
Charles R. Newton
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