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Pregnancy complications in women with polycystic ovary syndrome

Pregnancy complications in women with polycystic ovary syndrome
Pregnancy complications in women with polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. There is an increasing body of evidence indicating that PCOS may have significant implications for pregnancy outcomes and long-term health of a woman and her offspring. Whether or not PCOS itself or the symptoms that coincide with PCOS, like obesity and fertility treatment, are responsible for these increased risks is a continuing matter of debate. Miscarriage rates among women with PCOS are believed to be increased compared with normal fertile women, although supporting evidence is limited. Pregnant women with PCOS experience a higher incidence of perinatal morbidity from gestational diabetes, pregnancy-induced hypertension, and preeclampsia. Their babies are at an increased risk of neonatal complications, such as preterm birth and admission at a neonatal intensive care unit. Pre-pregnancy, antenatal, and intrapartum care should be aimed at reducing these risks. The use of insulin sensitizing drugs to decrease hyperinsulinemic insulin resistance has been proposed during pregnancy to reduce the risk of developing preeclampsia or gestational diabetes. Although metformin appears to be safe, there are too few data from prospective, randomized controlled trials to support treatment during pregnancy.
Polycystic ovary syndrome, pregnancy complications, pregnancy outcome
72-84
Boomsma, Carolien M
f0ab5958-b5e2-4fc7-910b-14db53a4c446
Fauser, Bart C.J.M
4e22d989-6319-4ddd-a2a5-f373c7a1aed0
Macklon, Nick S
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Boomsma, Carolien M
f0ab5958-b5e2-4fc7-910b-14db53a4c446
Fauser, Bart C.J.M
4e22d989-6319-4ddd-a2a5-f373c7a1aed0
Macklon, Nick S
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e

Boomsma, Carolien M, Fauser, Bart C.J.M and Macklon, Nick S (2008) Pregnancy complications in women with polycystic ovary syndrome. Seminars in Reproductive Medicine, 26 (1), 72-84. (doi:10.1055/s-2007-992927).

Record type: Article

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. There is an increasing body of evidence indicating that PCOS may have significant implications for pregnancy outcomes and long-term health of a woman and her offspring. Whether or not PCOS itself or the symptoms that coincide with PCOS, like obesity and fertility treatment, are responsible for these increased risks is a continuing matter of debate. Miscarriage rates among women with PCOS are believed to be increased compared with normal fertile women, although supporting evidence is limited. Pregnant women with PCOS experience a higher incidence of perinatal morbidity from gestational diabetes, pregnancy-induced hypertension, and preeclampsia. Their babies are at an increased risk of neonatal complications, such as preterm birth and admission at a neonatal intensive care unit. Pre-pregnancy, antenatal, and intrapartum care should be aimed at reducing these risks. The use of insulin sensitizing drugs to decrease hyperinsulinemic insulin resistance has been proposed during pregnancy to reduce the risk of developing preeclampsia or gestational diabetes. Although metformin appears to be safe, there are too few data from prospective, randomized controlled trials to support treatment during pregnancy.

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More information

Published date: 2008
Additional Information: PMID: 18181085
Keywords: Polycystic ovary syndrome, pregnancy complications, pregnancy outcome

Identifiers

Local EPrints ID: 149119
URI: https://eprints.soton.ac.uk/id/eprint/149119
PURE UUID: 189969bb-6cef-4a0d-b479-2a80de21411c

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Date deposited: 06 May 2010 09:13
Last modified: 18 Jul 2017 19:30

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Contributors

Author: Carolien M Boomsma
Author: Bart C.J.M Fauser
Author: Nick S Macklon

University divisions

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