Glucose tolerance, insulin resistance and insulin secretion in young South Indian adults: relationships to parental size, neonatal size and childhood body mass index
Glucose tolerance, insulin resistance and insulin secretion in young South Indian adults: relationships to parental size, neonatal size and childhood body mass index
Objective
To study the relationship of newborn size and post-natal growth to glucose intolerance in south Indian adults.
Research design and methods
2218 men and women (mean age 28 years) were studied from a population-based birth cohort born in a large town and adjacent rural villages. The prevalence of adult diabetes mellitus [DM] and impaired glucose tolerance [IGT], and insulin resistance and insulin secretion (calculated) were examined in relation to BMI and height at birth, and in infancy, childhood and adolescence and changes in BMI and height between these stages.
Results
Sixty-two (2.8%) subjects had Type 2 diabetes (DM) and 362 (16.3%) had impaired glucose tolerance (IGT). IGT and DM combined (IGT/DM) and insulin resistance were associated with low childhood body mass index (BMI) (p < 0.001 for both) and above-average BMI gain between childhood or adolescence and adult life (p < 0.001 for both). There were no direct associations between birthweight or infant size and IGT/DM; however, after adjusting for adult BMI, lower birthweight was associated with an increased risk.
Conclusions
The occurrence of IGT and Type 2 DM is associated with thinness at birth and in childhood followed by accelerated BMI gain through adolescence.
type 2 diabetes mellitus, impaired glucose tolerance, insulin resistance, childhood body mass index, young adulthood
283-292
Raghupathy, Palany
76cc790f-9c8d-4085-b9d0-27a26a316e40
Antonisamy, Belavendra
ec356bbb-f468-48a3-a375-ec2f3b20852a
Geethanjali, Finney S.
a3e2b129-87f5-40de-bcaf-af4f2e76a500
Saperia, Julia
b122e6e0-a381-4d7f-829b-c3f26fba8387
Leary, Samantha D.
396fbfba-d22b-4725-ba2f-6cf551588570
Priya, G.
b5cd6adb-c6a0-4345-b8a4-fc7d5b1c6fe9
Richard, Joseph
14a6f429-f478-4ae7-9783-22dfb6c4055d
Barker, David J.P.
84efdf7a-7c52-45fc-aa16-9647f3743c27
Fall, Caroline H.D.
7171a105-34f5-4131-89d7-1aa639893b18
February 2010
Raghupathy, Palany
76cc790f-9c8d-4085-b9d0-27a26a316e40
Antonisamy, Belavendra
ec356bbb-f468-48a3-a375-ec2f3b20852a
Geethanjali, Finney S.
a3e2b129-87f5-40de-bcaf-af4f2e76a500
Saperia, Julia
b122e6e0-a381-4d7f-829b-c3f26fba8387
Leary, Samantha D.
396fbfba-d22b-4725-ba2f-6cf551588570
Priya, G.
b5cd6adb-c6a0-4345-b8a4-fc7d5b1c6fe9
Richard, Joseph
14a6f429-f478-4ae7-9783-22dfb6c4055d
Barker, David J.P.
84efdf7a-7c52-45fc-aa16-9647f3743c27
Fall, Caroline H.D.
7171a105-34f5-4131-89d7-1aa639893b18
Raghupathy, Palany, Antonisamy, Belavendra, Geethanjali, Finney S., Saperia, Julia, Leary, Samantha D., Priya, G., Richard, Joseph, Barker, David J.P. and Fall, Caroline H.D.
(2010)
Glucose tolerance, insulin resistance and insulin secretion in young South Indian adults: relationships to parental size, neonatal size and childhood body mass index.
Diabetes Research and Clinical Practice, 87 (2), .
(doi:10.1016/j.diabres.2009.11.015).
Abstract
Objective
To study the relationship of newborn size and post-natal growth to glucose intolerance in south Indian adults.
Research design and methods
2218 men and women (mean age 28 years) were studied from a population-based birth cohort born in a large town and adjacent rural villages. The prevalence of adult diabetes mellitus [DM] and impaired glucose tolerance [IGT], and insulin resistance and insulin secretion (calculated) were examined in relation to BMI and height at birth, and in infancy, childhood and adolescence and changes in BMI and height between these stages.
Results
Sixty-two (2.8%) subjects had Type 2 diabetes (DM) and 362 (16.3%) had impaired glucose tolerance (IGT). IGT and DM combined (IGT/DM) and insulin resistance were associated with low childhood body mass index (BMI) (p < 0.001 for both) and above-average BMI gain between childhood or adolescence and adult life (p < 0.001 for both). There were no direct associations between birthweight or infant size and IGT/DM; however, after adjusting for adult BMI, lower birthweight was associated with an increased risk.
Conclusions
The occurrence of IGT and Type 2 DM is associated with thinness at birth and in childhood followed by accelerated BMI gain through adolescence.
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More information
Published date: February 2010
Keywords:
type 2 diabetes mellitus, impaired glucose tolerance, insulin resistance, childhood body mass index, young adulthood
Identifiers
Local EPrints ID: 149611
URI: http://eprints.soton.ac.uk/id/eprint/149611
ISSN: 0168-8227
PURE UUID: 6367cf65-9ebb-4dc7-9fce-c06af24a40fa
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Date deposited: 30 Apr 2010 14:23
Last modified: 14 Mar 2024 02:34
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Contributors
Author:
Palany Raghupathy
Author:
Belavendra Antonisamy
Author:
Finney S. Geethanjali
Author:
Julia Saperia
Author:
Samantha D. Leary
Author:
G. Priya
Author:
Joseph Richard
Author:
David J.P. Barker
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