The impact of ovarian stimulation for IVF on the developing embryo
The impact of ovarian stimulation for IVF on the developing embryo
The use of assisted reproductive technologies (ART) has been increasing over the past three decades, and, in developed countries, ART account for 1-3% of annual births. In an attempt to compensate for inefficiencies in IVF procedures, patients undergo ovarian stimulation using high doses of exogenous gonadotrophins to allow retrieval of multiple oocytes in a single cycle. Although ovarian stimulation has an important role in ART, it may also have detrimental effects on oogenesis, embryo quality, endometrial receptivity and perinatal outcomes.
In this review, we consider the evidence for these effects and address possible underlying mechanisms. We conclude that such mechanisms are still poorly understood, and further knowledge is needed in order to increase the safety of ovarian stimulation and to reduce potential effects on embryo development and implantation, which will ultimately be translated into increased pregnancy rates and healthy offspring.
23-34
Santos, Margarida Avo
dc5e07b5-647e-49ca-9f19-a8f90eed45e7
Kuijk, Ewart W.
5817b868-fafd-4575-b5a5-7c0c15229331
Macklon, Nick S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
January 2010
Santos, Margarida Avo
dc5e07b5-647e-49ca-9f19-a8f90eed45e7
Kuijk, Ewart W.
5817b868-fafd-4575-b5a5-7c0c15229331
Macklon, Nick S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Santos, Margarida Avo, Kuijk, Ewart W. and Macklon, Nick S.
(2010)
The impact of ovarian stimulation for IVF on the developing embryo.
Reproduction, 139 (1), .
(doi:10.1530/REP-09-0187).
Abstract
The use of assisted reproductive technologies (ART) has been increasing over the past three decades, and, in developed countries, ART account for 1-3% of annual births. In an attempt to compensate for inefficiencies in IVF procedures, patients undergo ovarian stimulation using high doses of exogenous gonadotrophins to allow retrieval of multiple oocytes in a single cycle. Although ovarian stimulation has an important role in ART, it may also have detrimental effects on oogenesis, embryo quality, endometrial receptivity and perinatal outcomes.
In this review, we consider the evidence for these effects and address possible underlying mechanisms. We conclude that such mechanisms are still poorly understood, and further knowledge is needed in order to increase the safety of ovarian stimulation and to reduce potential effects on embryo development and implantation, which will ultimately be translated into increased pregnancy rates and healthy offspring.
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Published date: January 2010
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Local EPrints ID: 150479
URI: http://eprints.soton.ac.uk/id/eprint/150479
ISSN: 0022-4251
PURE UUID: c7b3a7a6-d9b2-4203-bf6d-85a9533216d7
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Date deposited: 05 May 2010 13:52
Last modified: 14 Mar 2024 01:17
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Author:
Margarida Avo Santos
Author:
Ewart W. Kuijk
Author:
Nick S. Macklon
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