Anti-Mullerian hormone (AMH): what do we still need to know?
Anti-Mullerian hormone (AMH): what do we still need to know?
In the ovary, Anti-Müllerian hormone (AMH) is produced by the granulosa cells of early developing follicles and inhibits the transition from the primordial to the primary follicular stage. AMH levels can be measured in serum and have been shown to be proportional to the number of small antral follicles. In women serum AMH levels decrease with age and are undetectable in the post-menopausal period. In patients with premature ovarian failure AMH is undetectable or greatly reduced depending of the number of antral follicles in the ovaries. In contrast, AMH levels have been shown to be increased in women with polycystic ovary syndrome (PCOS). AMH levels appear to represent the quantity of the ovarian follicle pool and may become a useful marker of ovarian reserve. AMH measurement could also be useful in the prediction of the extremes of ovarian response to gonadotrophin stimulation for in vitro fertilization, namely poor- and hyper-response. Although AMH has the potential to increase our understanding of ovarian pathophysiology, and to guide clinical management in a broad range of conditions, a number of important questions relating to both the basic physiology of AMH and its clinical implications need to be answered.
PMID: 19520713 [PubMed - indexed for MEDLINE]
AMH, PCOS, ovarian reserve, infertility, ART
2264-2275
La Marca, A.
5209e947-cdd8-4d22-98ed-e4221ce6bb9b
Broekmans, F.J.
17ce14de-42f9-43cb-98be-194dc9430888
Volpe, A.
f5dfba32-3b50-4c9f-9390-f1b4851d321d
Fauser, B.C.
a74bd2e3-1d5e-43c1-a6e8-c67c4973f484
Macklon, N.S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
September 2009
La Marca, A.
5209e947-cdd8-4d22-98ed-e4221ce6bb9b
Broekmans, F.J.
17ce14de-42f9-43cb-98be-194dc9430888
Volpe, A.
f5dfba32-3b50-4c9f-9390-f1b4851d321d
Fauser, B.C.
a74bd2e3-1d5e-43c1-a6e8-c67c4973f484
Macklon, N.S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
La Marca, A., Broekmans, F.J., Volpe, A., Fauser, B.C. and Macklon, N.S.
(2009)
Anti-Mullerian hormone (AMH): what do we still need to know?
Human Reproduction, 24 (9), .
(doi:10.1093/humrep/dep210).
Abstract
In the ovary, Anti-Müllerian hormone (AMH) is produced by the granulosa cells of early developing follicles and inhibits the transition from the primordial to the primary follicular stage. AMH levels can be measured in serum and have been shown to be proportional to the number of small antral follicles. In women serum AMH levels decrease with age and are undetectable in the post-menopausal period. In patients with premature ovarian failure AMH is undetectable or greatly reduced depending of the number of antral follicles in the ovaries. In contrast, AMH levels have been shown to be increased in women with polycystic ovary syndrome (PCOS). AMH levels appear to represent the quantity of the ovarian follicle pool and may become a useful marker of ovarian reserve. AMH measurement could also be useful in the prediction of the extremes of ovarian response to gonadotrophin stimulation for in vitro fertilization, namely poor- and hyper-response. Although AMH has the potential to increase our understanding of ovarian pathophysiology, and to guide clinical management in a broad range of conditions, a number of important questions relating to both the basic physiology of AMH and its clinical implications need to be answered.
PMID: 19520713 [PubMed - indexed for MEDLINE]
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Published date: September 2009
Keywords:
AMH, PCOS, ovarian reserve, infertility, ART
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Local EPrints ID: 150489
URI: http://eprints.soton.ac.uk/id/eprint/150489
PURE UUID: f73081f5-4c5f-4813-a9fb-f8aac0ec7f37
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Date deposited: 05 May 2010 13:24
Last modified: 14 Mar 2024 01:17
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Author:
A. La Marca
Author:
F.J. Broekmans
Author:
A. Volpe
Author:
B.C. Fauser
Author:
N.S. Macklon
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