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Preconception folic acid treatment affects the microenvironment of the maturing oocyte in humans

Preconception folic acid treatment affects the microenvironment of the maturing oocyte in humans
Preconception folic acid treatment affects the microenvironment of the maturing oocyte in humans
Objective: to investigate the influence of folic acid supplementation on the follicular fluid concentrations of folate and total homocysteine and their relationship to the diameter of the follicle.

Design: observational study.

Setting: tertiary referral fertility clinic at the Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

Patient(s): thirty-seven women undergoing IVF or intracytoplasmic sperm injection treatment.

Intervention(s): no interventions other than routine stimulation treatment and the recommendation of folic acid supplementation.

Main Outcome Measure(s): concentrations of folate and total homocysteine in monofollicular and pooled follicular fluid and the diameter of the follicle.

Result(s): folic acid supplementation significantly increased folate and decreased total homocysteine concentrations in pooled follicular fluid. In monofollicular fluid, folate concentrations only were significantly increased in supplemented women. The total homocysteine concentration appeared to be significantly correlated with the diameter of the follicle (r = 0.27). Samples from single follicles were less prone to artifacts in the measurements of the folate and total homocysteine concentration.

Conclusion(s): preconception folic acid supplementation significantly alters both folate and total homocysteine concentrations in follicular fluid. The correlation between the diameter of the follicle and total homocysteine concentration in follicular fluid warrants further investigation.
ovary, follicular fluid, folate, homocysteine, supplementation, follicular diameter
0015-0282
1766-1770
Boxmeer, Jolanda C.
0c509cdc-e589-45d1-809c-dec6a025ba75
Brouns, R. Montserrate
8d2d9c42-5268-4b96-b67b-e355b6658200
Lindemans, Jan
2fe464f3-b659-460c-bde3-c54982286c0c
Steegers, Eric A.P.
6061f35a-1c75-4f9f-ac9f-ed369f475ce9
Martini, Elena
1a304077-2e5b-4865-b0d3-e07bec8f2489
Macklon, Nick S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Steegers-Theunissen, Régine P.
134c5e64-5b09-41f7-92fc-ae591a1c5527
Boxmeer, Jolanda C.
0c509cdc-e589-45d1-809c-dec6a025ba75
Brouns, R. Montserrate
8d2d9c42-5268-4b96-b67b-e355b6658200
Lindemans, Jan
2fe464f3-b659-460c-bde3-c54982286c0c
Steegers, Eric A.P.
6061f35a-1c75-4f9f-ac9f-ed369f475ce9
Martini, Elena
1a304077-2e5b-4865-b0d3-e07bec8f2489
Macklon, Nick S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Steegers-Theunissen, Régine P.
134c5e64-5b09-41f7-92fc-ae591a1c5527

Boxmeer, Jolanda C., Brouns, R. Montserrate, Lindemans, Jan, Steegers, Eric A.P., Martini, Elena, Macklon, Nick S. and Steegers-Theunissen, Régine P. (2008) Preconception folic acid treatment affects the microenvironment of the maturing oocyte in humans. Fertility and Sterility, 89 (6), 1766-1770. (doi:10.1016/j.fertnstert.2007.06.036).

Record type: Article

Abstract

Objective: to investigate the influence of folic acid supplementation on the follicular fluid concentrations of folate and total homocysteine and their relationship to the diameter of the follicle.

Design: observational study.

Setting: tertiary referral fertility clinic at the Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

Patient(s): thirty-seven women undergoing IVF or intracytoplasmic sperm injection treatment.

Intervention(s): no interventions other than routine stimulation treatment and the recommendation of folic acid supplementation.

Main Outcome Measure(s): concentrations of folate and total homocysteine in monofollicular and pooled follicular fluid and the diameter of the follicle.

Result(s): folic acid supplementation significantly increased folate and decreased total homocysteine concentrations in pooled follicular fluid. In monofollicular fluid, folate concentrations only were significantly increased in supplemented women. The total homocysteine concentration appeared to be significantly correlated with the diameter of the follicle (r = 0.27). Samples from single follicles were less prone to artifacts in the measurements of the folate and total homocysteine concentration.

Conclusion(s): preconception folic acid supplementation significantly alters both folate and total homocysteine concentrations in follicular fluid. The correlation between the diameter of the follicle and total homocysteine concentration in follicular fluid warrants further investigation.

Full text not available from this repository.

More information

Published date: June 2008
Keywords: ovary, follicular fluid, folate, homocysteine, supplementation, follicular diameter

Identifiers

Local EPrints ID: 150575
URI: https://eprints.soton.ac.uk/id/eprint/150575
ISSN: 0015-0282
PURE UUID: 7ccdfd9c-7363-4fe7-bbb9-ab1ba6280e85

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Date deposited: 05 May 2010 15:04
Last modified: 18 Jul 2017 19:17

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Contributors

Author: Jolanda C. Boxmeer
Author: R. Montserrate Brouns
Author: Jan Lindemans
Author: Eric A.P. Steegers
Author: Elena Martini
Author: Nick S. Macklon
Author: Régine P. Steegers-Theunissen

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