The guideline 'Recurrent Miscarriage' (first revision) of the Dutch society for obstetrics and gynaecology

Goddijn, M., van den Boogaard, E., Steepers, E.A., Erwich, J.J., Macklon, N. and Steegers-Theunissen, R.P. (2008) The guideline 'Recurrent Miscarriage' (first revision) of the Dutch society for obstetrics and gynaecology. Nederlands Tijdschrift voor Geneeskunde, 152 (30), 1665-1670.

Abstract

In 2007, the Dutch Society for Obstetrics and Gynaecology issued a revised version of the 1999 guideline on recurrent miscarriage. --The new guideline was developed according to the principles of evidence-based guideline development and includes levels of evidence. --The guideline contains recommendations for effective diagnosis and treatment and explicitly mentions certain diagnostic tests and treatments that should be avoided. --After a thorough investigation of a couples'-history, the type of diagnostic tests that should be offered to the couple can be determined. Patients with a low risk of having cytogenetic abnormalities or thrombophilia may be excluded from parental karyotyping and thrombophilia screening, respectively. --Women with confirmed antiphospholipid antibody syndrome should be offered anticoagulation treatment before and during subsequent pregnancies. --Effective therapy for unexplained recurrent miscarriage is lacking. However, the probability of a successful future pregnancy is high. This probability can be estimated based on the number of previous miscarriages and maternal age.

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