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The epidemiology of osteonecrosis: findings from the GPRD and thin databases in the uk.

The epidemiology of osteonecrosis: findings from the GPRD and thin databases in the uk.
The epidemiology of osteonecrosis: findings from the GPRD and thin databases in the uk.
Summary

We conducted a case–control study to examine osteonecrosis (ON) incidence, patient characteristics, and selected potential risk factors using two health record databases in the UK. Statistically significant risk factors for ON included systemic corticosteroid use, hospitalization, referral or specialist visit, bone fracture, any cancer, osteoporosis, connective tissue disease, and osteoarthritis.

Introduction

The purpose of this case–control study was to examine the incidence of osteonecrosis (ON), patient characteristics, and selected potential risk factors for ON using two health record databases in the UK: the General Practice Research Database and The Health Improvement Network.

Methods

ON cases (n? =?792) were identified from 1989 to 2003 and individually matched (age, sex, and medical practice) up to six controls (n?=?4,660) with no record of ON. Possible risk factors were considered for inclusion based on a review of published literature. Annual incidence rates were computed, and a multivariable logistic regression model was derived to evaluate selected risk factors.

Results

ON of the hip represented the majority of cases (75.9%). Statistically significant risk factors for ON were systemic corticosteroid use in the previous 2 years, hospitalization, referral or specialist visit, bone fracture, any cancer, osteoporosis, connective tissue disease, and osteoarthritis within the past 5 years. Only 4.4% of ON cases were exposed to bisphosphonates within the previous 2 years.

Conclusions

This study provides further perspective on the descriptive epidemiology of ON. Studies utilizing more recent data may further elucidate the understanding of ON key predictors.
avascular necrosis, epidemiology, osteonecrosis, risk factors
0937-941X
569-577
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Steinbuch, M.
4d4ad2a4-93aa-4fcd-96e6-762848fdfaa0
Stevenson, R.
9b5b6be1-a1e4-4576-83d6-93a0c69484e2
Miday, R.
2330a9f9-80a1-4e44-b1f4-32e64fe2bacc
Watts, N. B.
5dac1dfe-2fee-4fb4-942d-e28c0c29fdf5
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Steinbuch, M.
4d4ad2a4-93aa-4fcd-96e6-762848fdfaa0
Stevenson, R.
9b5b6be1-a1e4-4576-83d6-93a0c69484e2
Miday, R.
2330a9f9-80a1-4e44-b1f4-32e64fe2bacc
Watts, N. B.
5dac1dfe-2fee-4fb4-942d-e28c0c29fdf5

Cooper, C., Steinbuch, M., Stevenson, R., Miday, R. and Watts, N. B. (2010) The epidemiology of osteonecrosis: findings from the GPRD and thin databases in the uk. Osteoporosis International, 21 (4), 569-577. (doi:10.1007/s00198-009-1003-1).

Record type: Article

Abstract

Summary

We conducted a case–control study to examine osteonecrosis (ON) incidence, patient characteristics, and selected potential risk factors using two health record databases in the UK. Statistically significant risk factors for ON included systemic corticosteroid use, hospitalization, referral or specialist visit, bone fracture, any cancer, osteoporosis, connective tissue disease, and osteoarthritis.

Introduction

The purpose of this case–control study was to examine the incidence of osteonecrosis (ON), patient characteristics, and selected potential risk factors for ON using two health record databases in the UK: the General Practice Research Database and The Health Improvement Network.

Methods

ON cases (n? =?792) were identified from 1989 to 2003 and individually matched (age, sex, and medical practice) up to six controls (n?=?4,660) with no record of ON. Possible risk factors were considered for inclusion based on a review of published literature. Annual incidence rates were computed, and a multivariable logistic regression model was derived to evaluate selected risk factors.

Results

ON of the hip represented the majority of cases (75.9%). Statistically significant risk factors for ON were systemic corticosteroid use in the previous 2 years, hospitalization, referral or specialist visit, bone fracture, any cancer, osteoporosis, connective tissue disease, and osteoarthritis within the past 5 years. Only 4.4% of ON cases were exposed to bisphosphonates within the previous 2 years.

Conclusions

This study provides further perspective on the descriptive epidemiology of ON. Studies utilizing more recent data may further elucidate the understanding of ON key predictors.

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More information

Published date: April 2010
Keywords: avascular necrosis, epidemiology, osteonecrosis, risk factors

Identifiers

Local EPrints ID: 150751
URI: http://eprints.soton.ac.uk/id/eprint/150751
ISSN: 0937-941X
PURE UUID: e81b9726-fac6-481b-81f3-e85ad0961739
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 06 May 2010 10:16
Last modified: 18 Mar 2024 02:44

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Contributors

Author: C. Cooper ORCID iD
Author: M. Steinbuch
Author: R. Stevenson
Author: R. Miday
Author: N. B. Watts

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