Early life factor in the pathogenesis of osteoporosis
Early life factor in the pathogenesis of osteoporosis
Osteoporosis is a major public health burden through associated fragility fractures. Bone mass, a composite of bone size and volumetric density, increases through early life and childhood to a peak in early adulthood. The peak bone mass attained is a strong predictor of future risk of osteoporosis. Evidence is accruing that environmental factors in utero and in early infancy may permanently modify the postnatal pattern of skeletal growth to peak and thus influence risk of osteoporosis in later life. This article describes the latest data in this exciting area of research, including novel epigenetic and translation work, which should help to elucidate the underlying mechanisms and give rise to potential public health interventions to reduce the burden of osteoporotic fracture in future generations.
140-144
Winsloe, Chivon
6ddbe642-4cc9-4d91-9b2d-510fd7046d64
Earl, Susannah
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Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, Cyrus
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Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
December 2009
Winsloe, Chivon
6ddbe642-4cc9-4d91-9b2d-510fd7046d64
Earl, Susannah
23a453f9-0a79-4595-b7ed-22f90ac03c04
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Winsloe, Chivon, Earl, Susannah, Dennison, Elaine M., Cooper, Cyrus and Harvey, Nicholas
(2009)
Early life factor in the pathogenesis of osteoporosis.
Current Osteoporosis Reports, 7 (4), .
(doi:10.1007/s11914-009-0024-1).
Abstract
Osteoporosis is a major public health burden through associated fragility fractures. Bone mass, a composite of bone size and volumetric density, increases through early life and childhood to a peak in early adulthood. The peak bone mass attained is a strong predictor of future risk of osteoporosis. Evidence is accruing that environmental factors in utero and in early infancy may permanently modify the postnatal pattern of skeletal growth to peak and thus influence risk of osteoporosis in later life. This article describes the latest data in this exciting area of research, including novel epigenetic and translation work, which should help to elucidate the underlying mechanisms and give rise to potential public health interventions to reduce the burden of osteoporotic fracture in future generations.
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Published date: December 2009
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Local EPrints ID: 150779
URI: http://eprints.soton.ac.uk/id/eprint/150779
PURE UUID: 234792ca-028e-4c44-8ba7-cce37ea19736
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Date deposited: 06 May 2010 11:56
Last modified: 18 Mar 2024 02:58
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Author:
Chivon Winsloe
Author:
Susannah Earl
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