Brain natriuretic peptide for the prediction of sudden cardiac death and ventricular arrhythmias: a meta-analysis
Brain natriuretic peptide for the prediction of sudden cardiac death and ventricular arrhythmias: a meta-analysis
Aims
The risk stratification of patients for sudden cardiac death (SCD) remains a challenge. Brain natriuretic peptide (BNP) predicts overall mortality in heart disease but it is unclear how well it predicts SCD. We therefore performed a meta-analysis of studies evaluating the accuracy of BNP to predict SCD and ventricular arrhythmias (VA).
Methods and results
Electronic databases and published bibliographies were systematically searched (1984–2008). We found 14 studies that met our inclusion criteria. Six studies (3543 patients) evaluated BNP to predict SCD in patients without implantable cardioverter defibrillators (ICDs) across a wide range of populations. A raised BNP predicted SCD with a relative risk of 3.68 [95% confidence interval (CI) 1.90, 7.14]. Eight studies (1047 patients) evaluated BNP to predict the occurrence of VA in patients with ICDs. A raised BNP predicted the occurrence of VA with a relative risk of 2.54 (95% CI 1.87, 3.44).
Conclusion
The measurement of BNP has significant value in predicting SCD and VA. However, the benefit of BNP testing in addition to other risk stratification tests is unclear and BNP needs to be evaluated prospectively in combination with other complementary risk stratification tools.
brain natriuretic peptide, sudden death, ventricular arrhythmias, meta-analysis
958-966
Scott, Paul A.
5a16b1f4-74d3-473f-9eeb-c2a823d690dc
Barry, James
32febc4f-7ca9-4c00-b001-a82a9a6515da
Roberts, Paul R.
193431e8-f9d5-48d6-8f62-ed9052b2571d
Morgan, John M.
ac98099e-241d-4551-bc98-709f6dfc8680
2009
Scott, Paul A.
5a16b1f4-74d3-473f-9eeb-c2a823d690dc
Barry, James
32febc4f-7ca9-4c00-b001-a82a9a6515da
Roberts, Paul R.
193431e8-f9d5-48d6-8f62-ed9052b2571d
Morgan, John M.
ac98099e-241d-4551-bc98-709f6dfc8680
Scott, Paul A., Barry, James, Roberts, Paul R. and Morgan, John M.
(2009)
Brain natriuretic peptide for the prediction of sudden cardiac death and ventricular arrhythmias: a meta-analysis.
European Journal of Heart Failure, 11 (10), .
(doi:10.1093/eurjhf/hfp123).
Abstract
Aims
The risk stratification of patients for sudden cardiac death (SCD) remains a challenge. Brain natriuretic peptide (BNP) predicts overall mortality in heart disease but it is unclear how well it predicts SCD. We therefore performed a meta-analysis of studies evaluating the accuracy of BNP to predict SCD and ventricular arrhythmias (VA).
Methods and results
Electronic databases and published bibliographies were systematically searched (1984–2008). We found 14 studies that met our inclusion criteria. Six studies (3543 patients) evaluated BNP to predict SCD in patients without implantable cardioverter defibrillators (ICDs) across a wide range of populations. A raised BNP predicted SCD with a relative risk of 3.68 [95% confidence interval (CI) 1.90, 7.14]. Eight studies (1047 patients) evaluated BNP to predict the occurrence of VA in patients with ICDs. A raised BNP predicted the occurrence of VA with a relative risk of 2.54 (95% CI 1.87, 3.44).
Conclusion
The measurement of BNP has significant value in predicting SCD and VA. However, the benefit of BNP testing in addition to other risk stratification tests is unclear and BNP needs to be evaluated prospectively in combination with other complementary risk stratification tools.
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More information
Published date: 2009
Keywords:
brain natriuretic peptide, sudden death, ventricular arrhythmias, meta-analysis
Identifiers
Local EPrints ID: 151097
URI: http://eprints.soton.ac.uk/id/eprint/151097
ISSN: 1388-9842
PURE UUID: 15dd9393-97e8-40c5-b01c-1c40dff305b0
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Date deposited: 07 May 2010 12:15
Last modified: 14 Mar 2024 01:19
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Contributors
Author:
Paul A. Scott
Author:
James Barry
Author:
Paul R. Roberts
Author:
John M. Morgan
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