The University of Southampton
University of Southampton Institutional Repository

Transiently beneficial insertions could maintain mobile DNA sequences in variable environments

Edwards, Richard J and Brookfield, John F.Y. (2003) Transiently beneficial insertions could maintain mobile DNA sequences in variable environments Molecular Biology and Evolution, 20, (1), pp. 30-37. (doi:10.1093/molbev/msg001). (PMID:12519903).

Record type: Article

Abstract

The maintenance of mobile DNA sequences in clonal organisms has been seen as a paradox. If selfish mobile sequences spread through genomes only by overreplication in transposition, then sexuality is necessary for their spread through populations. The persistence of bacterial transposable elements without obvious dominant selectable markers has previously been explained by horizontal transfer. However, advantageous insertions of mobile DNAs are known in bacteria. Here we model maintenance of an otherwise selfish mobile DNA element in a clonal species in which selection for null mutations occurs during one of two temporally alternating environments. Large areas of parameter space permit maintenance of mobile DNAs where, without selection, they would have gone extinct. Horizontal transfer diminishes, rather than enhances, mean copy number. In finite populations, effective population sizes are greatly reduced by selective sweeps, and mean copy number can be increased as the reduced variance in copy number results in reduced selection.

PDF edwards_brookfield_2003.pdf - Version of Record
Download (396kB)

More information

Published date: January 2003
Keywords: transient insertion mutations, transposable elements, mobile dna, insertion sequences

Identifiers

Local EPrints ID: 151155
URI: http://eprints.soton.ac.uk/id/eprint/151155
PURE UUID: ec980d1a-a3f8-4210-9d1a-33cb29143a2e

Catalogue record

Date deposited: 13 May 2010 12:53
Last modified: 18 Jul 2017 12:55

Export record

Altmetrics

Contributors

Author: Richard J Edwards
Author: John F.Y. Brookfield

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×