The University of Southampton
University of Southampton Institutional Repository

In preeclampsia, the placenta grows slowly along its minor axis

Kajantie, Eero, Thornburg, Kent L., Eriksson, Johan G., Osmond, Clive and Barker, David J.P. (2010) In preeclampsia, the placenta grows slowly along its minor axis International Journal of Developmental Biology, 54, (2-3), pp. 469-473. (doi:10.1387/ijdb.082833ek).

Record type: Article

Abstract

A small placental surface area at birth is associated with an increased risk of hypertension in the offspring in later life. Preeclampsia is associated with impaired implantation and with increased blood pressure in the offspring. We hypothesized that preeclampsia would be associated with a small placental surface area. We studied placental size in 6410 deliveries at the Helsinki University Central Hospital during 1934-44. 284 of the pregnancies were complicated by preeclampsia. 1855 were complicated by hypertension without proteinuria. The area of the placental surface was estimated from two diameters that were routinely recorded, a maximal diameter and a lesser one at right angles to it. Compared to normotensive pregnancies, the placentas from pregnancies complicated by preeclampsia had a reduced surface area and the surface was more oval. The thickness, however, was increased. When the two diameters were analyzed together, preeclampsia was not associated with the length of the maximal diameter, but was strongly associated with a short lesser diameter (p<0.0001). This was a graded relation: the shorter the lesser diameter, the greater the risk for, and severity of, preeclampsia. Placentas from pregnancies complicated by hypertension without proteinuria had a reduced surface area, with short lesser and maximal diameters. Processes that underlie preeclampsia may be closely related to the amount of placental tissue on the minor axis of the placenta. We postulated that placental growth is polarized from the time of implantation, so that growth along the major and minor axes is qualitatively different.

Full text not available from this repository.

More information

Published date: 2010
Keywords: placental surface, preeclampsia, pregnancy hypertension

Identifiers

Local EPrints ID: 151333
URI: http://eprints.soton.ac.uk/id/eprint/151333
ISSN: 0214-6282
PURE UUID: 19eb3579-e88e-4caa-9ca9-6d700f6e97ab
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655

Catalogue record

Date deposited: 10 May 2010 13:16
Last modified: 18 Jul 2017 12:55

Export record

Altmetrics

Contributors

Author: Eero Kajantie
Author: Kent L. Thornburg
Author: Johan G. Eriksson
Author: Clive Osmond ORCID iD
Author: David J.P. Barker

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×