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Dynamics of pneumococcal colonization in healthy Dutch children

Dynamics of pneumococcal colonization in healthy Dutch children
Dynamics of pneumococcal colonization in healthy Dutch children
A recent study of pneumococcal colonization in 3198 healthy children of 1-19 years of age in The Netherlands showed pneumococcal colonization in 19 % of the children, with a peak incidence of 55 % at the age of 2 years; an age-related serotype distribution was also found. In the present study, the genetic background and resistance profiles of 578 pneumococcal isolates from the latter study were characterized by means of chromosomal genotyping and susceptibility testing. In contrast to the age-related serotype distribution observed previously, the genetic background of the strains was not age related. Few strains were found showing close homology (>95 %) with the international clones Spain(9V)-3 (ten isolates showed homology), England(14)-9 (four isolates), Tennessee(23F)-4 (two isolates), CSR(14)-10 (one isolate) and Sweden(15A)-25 (one isolate). In total, 19 % of strains showed resistance to one or more antibiotics. Resistance to cotrimoxazole, tetracycline, erythromycin and penicillin was found in 12.9, 5.6, 5.0 and 2.7 % of isolates, respectively. Multidrug resistance was found in 1.9 % of strains. In conclusion, pneumococcal colonization isolates from healthy Dutch children represent a heterogeneous, mostly antibiotic susceptible, genetic population.

1350-0872
377-385
Bogaert, D.
a7284b06-0fe5-46d9-aef9-6e1da016f628
Sluijter, M.
d6f31baf-a301-4748-b904-b808a0402ed0
Lemmens-Den Toom, N.
96b45310-fae4-4403-a2d5-9320a5f5c0c2
Mitchell, T.J.
927279e4-ea84-4ad0-aa32-314f0f3ae8e9
Goessens, W.H.F.
2ed4ab0b-9eae-4a17-9577-2aa0f5533af9
Clarke, Stuart C.
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
De Groot, R.
f00aeeb2-0461-452c-b247-4e1800dea908
Hermans, P.W.M.
434f2b68-bfdd-4b71-a94d-3c08ff669a88
Bogaert, D.
a7284b06-0fe5-46d9-aef9-6e1da016f628
Sluijter, M.
d6f31baf-a301-4748-b904-b808a0402ed0
Lemmens-Den Toom, N.
96b45310-fae4-4403-a2d5-9320a5f5c0c2
Mitchell, T.J.
927279e4-ea84-4ad0-aa32-314f0f3ae8e9
Goessens, W.H.F.
2ed4ab0b-9eae-4a17-9577-2aa0f5533af9
Clarke, Stuart C.
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
De Groot, R.
f00aeeb2-0461-452c-b247-4e1800dea908
Hermans, P.W.M.
434f2b68-bfdd-4b71-a94d-3c08ff669a88

Bogaert, D., Sluijter, M., Lemmens-Den Toom, N., Mitchell, T.J., Goessens, W.H.F., Clarke, Stuart C., De Groot, R. and Hermans, P.W.M. (2006) Dynamics of pneumococcal colonization in healthy Dutch children. Microbiology, 152, part 2, 377-385.

Record type: Article

Abstract

A recent study of pneumococcal colonization in 3198 healthy children of 1-19 years of age in The Netherlands showed pneumococcal colonization in 19 % of the children, with a peak incidence of 55 % at the age of 2 years; an age-related serotype distribution was also found. In the present study, the genetic background and resistance profiles of 578 pneumococcal isolates from the latter study were characterized by means of chromosomal genotyping and susceptibility testing. In contrast to the age-related serotype distribution observed previously, the genetic background of the strains was not age related. Few strains were found showing close homology (>95 %) with the international clones Spain(9V)-3 (ten isolates showed homology), England(14)-9 (four isolates), Tennessee(23F)-4 (two isolates), CSR(14)-10 (one isolate) and Sweden(15A)-25 (one isolate). In total, 19 % of strains showed resistance to one or more antibiotics. Resistance to cotrimoxazole, tetracycline, erythromycin and penicillin was found in 12.9, 5.6, 5.0 and 2.7 % of isolates, respectively. Multidrug resistance was found in 1.9 % of strains. In conclusion, pneumococcal colonization isolates from healthy Dutch children represent a heterogeneous, mostly antibiotic susceptible, genetic population.

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Published date: 2006

Identifiers

Local EPrints ID: 151831
URI: https://eprints.soton.ac.uk/id/eprint/151831
ISSN: 1350-0872
PURE UUID: 96b71027-ace0-4f91-9178-fffff352f88f
ORCID for Stuart C. Clarke: ORCID iD orcid.org/0000-0002-7009-1548

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Date deposited: 21 Jun 2010 11:27
Last modified: 06 Jun 2018 12:39

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