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Osteoporosis and venous thromboembolism: a retrospective cohort study in the UK general practice research database

Osteoporosis and venous thromboembolism: a retrospective cohort study in the UK general practice research database
Osteoporosis and venous thromboembolism: a retrospective cohort study in the UK general practice research database
Summary:

In a retrospective cohort study using the General Practice Research Database (GPRD), there was a greater association of venous thromboembolism (VTE) in osteoporotic than in non-osteoporotic female patients. No greater association was shown in treated patients with strontium ranelate or alendronate compared to untreated osteoporotic female patients.

Introduction

We explored the risk of VTE in usual practice in osteoporotic and non-osteoporotic women with and without anti-osteoporotic treatment.

Methods:

A retrospective study was conducted using the GPRD in the UK. The cohorts consisted of untreated osteoporotic women (N?=?11,546), osteoporotic women treated with alendronate (N?=?20,084), or strontium ranelate (N?=?2,408), and a sample of non-osteoporotic women (N?=?115,009). Cohorts were compared using a Cox proportional hazards regression model.

Results:

There was a significantly increased relative risk for VTE in untreated osteoporotic women versus non-osteoporotic women (annual incidence 5.6 and 3.2 per 1,000 patient–years, respectively; relative risk 1.75 [95% confidence interval (CI), 1.09–1.84]). Results were confirmed using adjusted models. The annual incidences of VTE in osteoporotic patients treated with strontium ranelate and alendronate were 7.0 and 7.2 per 1,000 patient–years, respectively, with no significant difference between untreated and treated patients whatever the treatment. Adjusted hazard ratios for treated versus untreated osteoporotic women were 1.09 (95% CI, 0.60–2.01) for strontium ranelate and 0.92 (95% CI, 0.63–1.33) for alendronate.

Conclusion:

This study shows a greater association of VTE in osteoporotic compared to non-osteoporotic patients, but does not show any greater association in treated patients with strontium ranelate or alendronate compared to untreated osteoporotic patients.
alendronate sodium, GPRD, osteoporosis, risk factors, strontium ranelate, venous thromboembolism
0937-941X
1181-1187
Breart, G.
6f2520fc-06ca-4edd-9701-4567f565bfd2
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Meyer, O.
4a681acd-4f32-4057-a28f-247fffae287c
Speirs, C.
f0f98fb1-19ed-4d8d-a4ce-485eb9958b32
Deltour, N.
260401d7-9bab-49d1-bfac-198266c1bb2a
Reginster, J. Y.
7de6c80d-0c90-4c29-a071-a7908edc631b
Breart, G.
6f2520fc-06ca-4edd-9701-4567f565bfd2
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Meyer, O.
4a681acd-4f32-4057-a28f-247fffae287c
Speirs, C.
f0f98fb1-19ed-4d8d-a4ce-485eb9958b32
Deltour, N.
260401d7-9bab-49d1-bfac-198266c1bb2a
Reginster, J. Y.
7de6c80d-0c90-4c29-a071-a7908edc631b

Breart, G., Cooper, C., Meyer, O., Speirs, C., Deltour, N. and Reginster, J. Y. (2010) Osteoporosis and venous thromboembolism: a retrospective cohort study in the UK general practice research database. Osteoporosis International, 27 (7), 1181-1187. (doi:10.1007/s00198-009-1050-7).

Record type: Article

Abstract

Summary:

In a retrospective cohort study using the General Practice Research Database (GPRD), there was a greater association of venous thromboembolism (VTE) in osteoporotic than in non-osteoporotic female patients. No greater association was shown in treated patients with strontium ranelate or alendronate compared to untreated osteoporotic female patients.

Introduction

We explored the risk of VTE in usual practice in osteoporotic and non-osteoporotic women with and without anti-osteoporotic treatment.

Methods:

A retrospective study was conducted using the GPRD in the UK. The cohorts consisted of untreated osteoporotic women (N?=?11,546), osteoporotic women treated with alendronate (N?=?20,084), or strontium ranelate (N?=?2,408), and a sample of non-osteoporotic women (N?=?115,009). Cohorts were compared using a Cox proportional hazards regression model.

Results:

There was a significantly increased relative risk for VTE in untreated osteoporotic women versus non-osteoporotic women (annual incidence 5.6 and 3.2 per 1,000 patient–years, respectively; relative risk 1.75 [95% confidence interval (CI), 1.09–1.84]). Results were confirmed using adjusted models. The annual incidences of VTE in osteoporotic patients treated with strontium ranelate and alendronate were 7.0 and 7.2 per 1,000 patient–years, respectively, with no significant difference between untreated and treated patients whatever the treatment. Adjusted hazard ratios for treated versus untreated osteoporotic women were 1.09 (95% CI, 0.60–2.01) for strontium ranelate and 0.92 (95% CI, 0.63–1.33) for alendronate.

Conclusion:

This study shows a greater association of VTE in osteoporotic compared to non-osteoporotic patients, but does not show any greater association in treated patients with strontium ranelate or alendronate compared to untreated osteoporotic patients.

Full text not available from this repository.

More information

Published date: July 2010
Keywords: alendronate sodium, GPRD, osteoporosis, risk factors, strontium ranelate, venous thromboembolism

Identifiers

Local EPrints ID: 152077
URI: http://eprints.soton.ac.uk/id/eprint/152077
ISSN: 0937-941X
PURE UUID: 158ec7de-48d8-4d82-80e6-051c3be8d820
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 13 May 2010 13:44
Last modified: 10 Dec 2019 01:52

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