Cost-effectiveness of balloon kyphoplasty in patients with symptomatic vertebral compression fractures in a UK setting
Cost-effectiveness of balloon kyphoplasty in patients with symptomatic vertebral compression fractures in a UK setting
Summary: Balloon kyphoplasty (BKP) is a procedure used to treat vertebral compression fractures (VCFs). We developed a cost-effectiveness model to evaluate BKP in United Kingsdom patients with hospitalised VCFs and estimated the cost-effectiveness of BKP compared to non-surgical management. The results indicate that BKP provides a cost-effective alternative for treating these patients.
Introduction: VCFs of osteoporotic patients are associated with chronic pain, a reduction in health-related quality of life (QoL) and high healthcare costs. BKP is a minimally invasive procedure that has resulted in pain relief, vertebral body height-restoration, decreased kyphosis and improved physical functioning in patients with symptomatic VCFs. BKP was shown to improve health-related QoL in a 12-month interim analysis of a randomised phase-III trial.
Methods: The objectives of this study were to develop a Markov cost-effectiveness model to evaluate BKP in patients with painful hospitalised VCFs and to estimate the cost-effectiveness of BKP compared with non-surgical management in a UK setting. It was assumed that QoL-benefits found at 12 months linearly approached zero during another 2 years, and that patients receiving BKP warranted six fewer hospital bed days compared with patients given non-surgical management.
Results: The procedure was associated with quality-adjusted life-years (QALY)-gains of 0.17 and cost/QALY-gains at pound8,800. The results were sensitive to assumptions about avoided length of hospital-stay and persistence of kyphoplasty-related QoL-benefits.
Conclusion: In conclusion, the results indicate that BKP provides a cost-effective alternative for treating patients with hospitalised VCFs in a UK-setting.
hta, markov, osteoporosis, qaly, uk
Strom, O.
b35a1ed8-a739-44d7-a058-a55e703fcdba
Leonard, C.
6d10e9bd-7ddc-4e4e-95d1-40864d12574a
Marsh, D.
7c06e90c-dfd8-4717-8907-b304f8773d36
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
19 November 2009
Strom, O.
b35a1ed8-a739-44d7-a058-a55e703fcdba
Leonard, C.
6d10e9bd-7ddc-4e4e-95d1-40864d12574a
Marsh, D.
7c06e90c-dfd8-4717-8907-b304f8773d36
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Strom, O., Leonard, C., Marsh, D. and Cooper, C.
(2009)
Cost-effectiveness of balloon kyphoplasty in patients with symptomatic vertebral compression fractures in a UK setting.
Osteoporosis International.
(doi:10.1007/s00198-009-1096-6).
Abstract
Summary: Balloon kyphoplasty (BKP) is a procedure used to treat vertebral compression fractures (VCFs). We developed a cost-effectiveness model to evaluate BKP in United Kingsdom patients with hospitalised VCFs and estimated the cost-effectiveness of BKP compared to non-surgical management. The results indicate that BKP provides a cost-effective alternative for treating these patients.
Introduction: VCFs of osteoporotic patients are associated with chronic pain, a reduction in health-related quality of life (QoL) and high healthcare costs. BKP is a minimally invasive procedure that has resulted in pain relief, vertebral body height-restoration, decreased kyphosis and improved physical functioning in patients with symptomatic VCFs. BKP was shown to improve health-related QoL in a 12-month interim analysis of a randomised phase-III trial.
Methods: The objectives of this study were to develop a Markov cost-effectiveness model to evaluate BKP in patients with painful hospitalised VCFs and to estimate the cost-effectiveness of BKP compared with non-surgical management in a UK setting. It was assumed that QoL-benefits found at 12 months linearly approached zero during another 2 years, and that patients receiving BKP warranted six fewer hospital bed days compared with patients given non-surgical management.
Results: The procedure was associated with quality-adjusted life-years (QALY)-gains of 0.17 and cost/QALY-gains at pound8,800. The results were sensitive to assumptions about avoided length of hospital-stay and persistence of kyphoplasty-related QoL-benefits.
Conclusion: In conclusion, the results indicate that BKP provides a cost-effective alternative for treating patients with hospitalised VCFs in a UK-setting.
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Published date: 19 November 2009
Keywords:
hta, markov, osteoporosis, qaly, uk
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Local EPrints ID: 152129
URI: http://eprints.soton.ac.uk/id/eprint/152129
ISSN: 0937-941X
PURE UUID: 73a7989d-365a-47be-839a-ab2eb45c095b
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Date deposited: 13 May 2010 13:38
Last modified: 18 Mar 2024 02:44
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Author:
O. Strom
Author:
C. Leonard
Author:
D. Marsh
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