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Growth in childhood predicts hip fracture risk in later life

Growth in childhood predicts hip fracture risk in later life
Growth in childhood predicts hip fracture risk in later life
Summary: the incidence of hip fracture was estimated in 6,370 women born in Helsinki between 1934 and 1944. Women in the lowest quarter of adiposity gain had an 8.2-fold increase in hip fracture risk compared with those in the highest quarter (p?<?0.001). These data point to a relationship between childhood growth and fracture risk during later life.

Introduction: previous findings show that discordance between childhood increase in height and weight is associated with an increased risk of osteoporotic fractures during later life.

Methods: we studied 6,370 women born in Helsinki between 1934 and 1944. Each woman’s birth weight and length at birth was recorded, as well as her height and weight through childhood. We identified the occurrence of hip fracture through the National Finnish Hospital discharge register.

Results: there were 49 hip fractures in the 6,370 women over 187,238 person-years of follow-up. Hip fracture was associated with increasing Z-scores for height between 1 and 12 years, not matched by a corresponding increase in weight. Therefore, reduction in the Z-score for body mass index was associated with increased risk of hip fracture. Women in the lowest quarter of change in Z-scores for body mass index had an 8.2-fold increase in hip fracture risk (95% CI 1.9 to 35), compared with those in the highest quarter (p?<?0.001).

Conclusion: thinness in childhood is a risk factor for hip fracture in later life. This could be a direct effect of low fat mass on bone mineralization, or represent the influence of altered timing of pubertal maturation.
developmental origins, epidemiology, hip fracture, osteoporosis
0937-941X
69-73
Javaid, M.K.
51d3310b-032e-4c15-83ac-b878bce090f3
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
Kajantie, E.
d4e32f85-9988-4b83-b353-012210ea0151
Forsén, T.
636ecafb-05fa-46a7-a2d5-f5561e29dc6c
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, D.J.P.
64c6005a-eea7-4c26-8f07-50d875998512
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Javaid, M.K.
51d3310b-032e-4c15-83ac-b878bce090f3
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
Kajantie, E.
d4e32f85-9988-4b83-b353-012210ea0151
Forsén, T.
636ecafb-05fa-46a7-a2d5-f5561e29dc6c
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, D.J.P.
64c6005a-eea7-4c26-8f07-50d875998512
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6

Javaid, M.K., Eriksson, J.G., Kajantie, E., Forsén, T., Osmond, C., Barker, D.J.P. and Cooper, C. (2011) Growth in childhood predicts hip fracture risk in later life. Osteoporosis International, 22 (1), 69-73. (doi:10.1007/s00198-010-1224-3).

Record type: Article

Abstract

Summary: the incidence of hip fracture was estimated in 6,370 women born in Helsinki between 1934 and 1944. Women in the lowest quarter of adiposity gain had an 8.2-fold increase in hip fracture risk compared with those in the highest quarter (p?<?0.001). These data point to a relationship between childhood growth and fracture risk during later life.

Introduction: previous findings show that discordance between childhood increase in height and weight is associated with an increased risk of osteoporotic fractures during later life.

Methods: we studied 6,370 women born in Helsinki between 1934 and 1944. Each woman’s birth weight and length at birth was recorded, as well as her height and weight through childhood. We identified the occurrence of hip fracture through the National Finnish Hospital discharge register.

Results: there were 49 hip fractures in the 6,370 women over 187,238 person-years of follow-up. Hip fracture was associated with increasing Z-scores for height between 1 and 12 years, not matched by a corresponding increase in weight. Therefore, reduction in the Z-score for body mass index was associated with increased risk of hip fracture. Women in the lowest quarter of change in Z-scores for body mass index had an 8.2-fold increase in hip fracture risk (95% CI 1.9 to 35), compared with those in the highest quarter (p?<?0.001).

Conclusion: thinness in childhood is a risk factor for hip fracture in later life. This could be a direct effect of low fat mass on bone mineralization, or represent the influence of altered timing of pubertal maturation.

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More information

Published date: 9 January 2011
Keywords: developmental origins, epidemiology, hip fracture, osteoporosis

Identifiers

Local EPrints ID: 152185
URI: http://eprints.soton.ac.uk/id/eprint/152185
ISSN: 0937-941X
PURE UUID: 434da41b-ccfb-4147-b2ca-ad337e110c38
ORCID for C. Osmond: ORCID iD orcid.org/0000-0002-9054-4655
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 14 May 2010 09:10
Last modified: 18 Mar 2024 02:44

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Contributors

Author: M.K. Javaid
Author: J.G. Eriksson
Author: E. Kajantie
Author: T. Forsén
Author: C. Osmond ORCID iD
Author: D.J.P. Barker
Author: C. Cooper ORCID iD

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