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Are we getting to grips with Alzheimer's disease at last?

Are we getting to grips with Alzheimer's disease at last?
Are we getting to grips with Alzheimer's disease at last?
Recent statistics from the Alzheimer Research Trust suggest that in the UK alone 820 000 people are affected by dementia with a cost to the economy of £23 billion/year. Similar figures apply to all developed countries and most others are catching up rapidly. With increasing life expectancy, age-related dementia is seen globally as an urgent public health priority.

Histological examination of the brain is still regarded as the gold standard for diagnosis of the specific disease process underlying dementia, the commonest cause of which is Alzheimer’s disease. The main features of Alzheimer’s disease are extracellular accumulation of amyloid ?-protein (A?) in the form of plaques and in blood vessel walls as cerebral amyloid angiopathy; intraneuronal accumulation of tau protein forming tangles in neuronal cell bodies as well as in neuronal processes situated close to plaques (dystrophic neurites) and elsewhere (neuropil threads); activation of microglia and astrocytes; and neuronal and synaptic
0006-8950
1297-1299
Boche, Delphine
bdcca10e-6302-4dd0-919f-67218f7e0d61
Nicoll, James A R
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Boche, Delphine
bdcca10e-6302-4dd0-919f-67218f7e0d61
Nicoll, James A R
88c0685f-000e-4eb7-8f72-f36b4985e8ed

Boche, Delphine and Nicoll, James A R (2010) Are we getting to grips with Alzheimer's disease at last? Brain, 133 (5), 1297-1299. (doi:10.1093/brain/awq099).

Record type: Article

Abstract

Recent statistics from the Alzheimer Research Trust suggest that in the UK alone 820 000 people are affected by dementia with a cost to the economy of £23 billion/year. Similar figures apply to all developed countries and most others are catching up rapidly. With increasing life expectancy, age-related dementia is seen globally as an urgent public health priority.

Histological examination of the brain is still regarded as the gold standard for diagnosis of the specific disease process underlying dementia, the commonest cause of which is Alzheimer’s disease. The main features of Alzheimer’s disease are extracellular accumulation of amyloid ?-protein (A?) in the form of plaques and in blood vessel walls as cerebral amyloid angiopathy; intraneuronal accumulation of tau protein forming tangles in neuronal cell bodies as well as in neuronal processes situated close to plaques (dystrophic neurites) and elsewhere (neuropil threads); activation of microglia and astrocytes; and neuronal and synaptic

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Published date: May 2010
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 152233
URI: http://eprints.soton.ac.uk/id/eprint/152233
ISSN: 0006-8950
PURE UUID: 9ca0937b-fd8e-462c-83a4-59048cc6a178
ORCID for Delphine Boche: ORCID iD orcid.org/0000-0002-5884-130X
ORCID for James A R Nicoll: ORCID iD orcid.org/0000-0002-9444-7246

Catalogue record

Date deposited: 13 May 2010 15:18
Last modified: 20 Jul 2019 01:07

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