Fabrication of pillar-like titania nanostructures on titanium and their interactions with human skeletal stem cells
Fabrication of pillar-like titania nanostructures on titanium and their interactions with human skeletal stem cells
Surface nanotopography is known to influence the interaction of human skeletal (mesenchymal) stem cells (hMSC) with a material surface. While most surface nanopatterning has been performed on polymer-based surfaces there is a need for techniques to produce well-defined topography features with tuneable sizes on relevant load-bearing implant materials such as titanium (Ti).
In this study titania nanopillar structures with heights of either 15, 55 or 100 nm were produced on Ti surfaces using anodization through a porous alumina mask. The influence of the surface structure heights on hMSC adhesion, spreading, cytoskeletal formation and differentiation was examined. The 15 nm high topography features resulted in the greatest cell response with bone matrix nodule forming on the Ti surface after 21 days.
titanium, nanotopography, mesenchymal stem cell, In vitro test
1433-1441
Sjostrom, Terje
c1615dd5-a794-4b7a-ad5e-eff8df229b59
Dalby, Matthew J.
25dcae6a-8289-4169-abb7-c45fff0bafdc
Hart, Andrew
6011e639-937a-4d81-aa83-ba1ad25ca916
Tare, Rahul S.
587c9db4-e409-4e7c-a02a-677547ab724a
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Su, Bo
37e0f5b2-72ab-48e5-87c0-cabdfd83cc21
June 2009
Sjostrom, Terje
c1615dd5-a794-4b7a-ad5e-eff8df229b59
Dalby, Matthew J.
25dcae6a-8289-4169-abb7-c45fff0bafdc
Hart, Andrew
6011e639-937a-4d81-aa83-ba1ad25ca916
Tare, Rahul S.
587c9db4-e409-4e7c-a02a-677547ab724a
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Su, Bo
37e0f5b2-72ab-48e5-87c0-cabdfd83cc21
Sjostrom, Terje, Dalby, Matthew J., Hart, Andrew, Tare, Rahul S., Oreffo, Richard O.C. and Su, Bo
(2009)
Fabrication of pillar-like titania nanostructures on titanium and their interactions with human skeletal stem cells.
Acta Biomaterialia, 5 (5), .
(doi:10.1016/j.actbio.2009.01.007).
Abstract
Surface nanotopography is known to influence the interaction of human skeletal (mesenchymal) stem cells (hMSC) with a material surface. While most surface nanopatterning has been performed on polymer-based surfaces there is a need for techniques to produce well-defined topography features with tuneable sizes on relevant load-bearing implant materials such as titanium (Ti).
In this study titania nanopillar structures with heights of either 15, 55 or 100 nm were produced on Ti surfaces using anodization through a porous alumina mask. The influence of the surface structure heights on hMSC adhesion, spreading, cytoskeletal formation and differentiation was examined. The 15 nm high topography features resulted in the greatest cell response with bone matrix nodule forming on the Ti surface after 21 days.
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Published date: June 2009
Keywords:
titanium, nanotopography, mesenchymal stem cell, In vitro test
Identifiers
Local EPrints ID: 152335
URI: http://eprints.soton.ac.uk/id/eprint/152335
ISSN: 1742-7061
PURE UUID: 1f7bcc7e-7a28-4eb6-8adc-2568096845a5
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Date deposited: 14 May 2010 08:14
Last modified: 14 Mar 2024 02:49
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Contributors
Author:
Terje Sjostrom
Author:
Matthew J. Dalby
Author:
Andrew Hart
Author:
Bo Su
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