The University of Southampton
University of Southampton Institutional Repository

Enhancement of human bone marrow cell uptake of quantum dots using tat peptide

Berry, C.C., Harianawalw, H., Loebus, J., Oreffo, Richard O.C. and de la Fuente, J. (2009) Enhancement of human bone marrow cell uptake of quantum dots using tat peptide Current Nanoscience, 5, (4), pp. 390-395. (doi:10.2174/157341309789378122).

Record type: Article

Abstract

Nanotechnology is proving to play a major role in the future of biomedical applications such as drug delivery, gene therapy and cell imaging/tracking, in particular the use of nanoparticles is regularly highlighted. However with regards to nanoparticles, direct intracellular and intranuclear delivery has, until recently, been difficult to achieve due to the impermeable nature of the plasma and nuclear membranes. The advent of cell penetrating peptides being employed as delivery vectors has opened up many avenues with respect to targeted delivery systems.

In this paper, quantum dots were synthesised and functionalised with the HIV-1 tat peptide, and uptake into human bone marrow derived cell populations was assessed. Results demonstrated an increase in uptake for tat modified quantum dots, possibly via a different mechanism to non-modified dots.

Full text not available from this repository.

More information

Published date: November 2009
Keywords: cell, nanoparticles, quantum dots, tat peptide

Identifiers

Local EPrints ID: 152345
URI: http://eprints.soton.ac.uk/id/eprint/152345
PURE UUID: 5b781b6c-fbbb-4555-a40b-dfe4a4de6ab8
ORCID for Richard O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

Catalogue record

Date deposited: 14 May 2010 08:26
Last modified: 18 Jul 2017 12:54

Export record

Altmetrics

Contributors

Author: C.C. Berry
Author: H. Harianawalw
Author: J. Loebus
Author: J. de la Fuente

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×