Systematic review of the evidence base for the medical treatment of paediatric inflammatory bowel disease
Systematic review of the evidence base for the medical treatment of paediatric inflammatory bowel disease
Objective: to systematically review the evidence base for the medical (pharmaceutical and nutritional) treatment of paediatric inflammatory bowel disease.
Methods: key clinical questions were formulated regarding different treatment modalities used in the treatment of paediatric (not adult-onset) IBD, in particular the induction and maintenance of remission in Crohn disease and ulcerative colitis. Electronic searches were performed from January 1966 to December 2006, using the electronic search strategy of the Cochrane IBD group. Details of papers were entered on a dedicated database, reviewed in abstract form, and disseminated in full for appraisal. Clinical guidelines were appraised using the AGREE instrument and all other relevant papers were appraised using Scottish Intercollegiate Guidelines Network methodology, with evidence levels given to all papers.
Results: a total of 6285 papers were identified, of which 1255 involved children; these were entered on the database. After critical appraisal, only 103 publications met our criteria as evidence on medical treatment of paediatric IBD. We identified 3 clinical guidelines, 1 systematic review, and 16 randomised controlled trials; all were of variable quality, with none getting the highest methodological scores.
Conclusions: this is the first comprehensive review of the evidence base for the treatment of paediatric IBD, highlighting the paucity of trials of high methodological quality. As a result, the development of clinical guidelines for managing children and young people with IBD must be consensus based, informed by the best-available evidence from the paediatric literature and high-quality data from the adult IBD literature, together with the clinical expertise and multidisciplinary experience of paediatric IBD experts.
S14-S34
Wilson, D.C.
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Thomas, A.G.
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Croft, N.M.
1be944c3-d2aa-4290-b17b-1e54ad84c125
Newby, E.
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Akobeng, A.K.
4d33278c-baf5-4995-8613-61c98151c937
Sawczenko, A.
5bd099d6-8579-4346-a480-2d72be520777
Fell, J.M.E.
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Murphy, M.S.
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Beattie, R.M.
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Sandhu, B.K.
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Mitton, S.G.
bf7c3e5d-e1ac-4053-ab83-72500110e4b5
IBD Working Group of the British Society of Paediatric Gastroenterology, Hepatology, and Nutrition
February 2010
Wilson, D.C.
2d86e1f9-76cb-4ff0-9db8-925711b8aca2
Thomas, A.G.
9003d635-970e-4c9b-9cc7-5e68a3706cb0
Croft, N.M.
1be944c3-d2aa-4290-b17b-1e54ad84c125
Newby, E.
7be7d5da-6ad2-4d2a-bac2-654cc9a6169f
Akobeng, A.K.
4d33278c-baf5-4995-8613-61c98151c937
Sawczenko, A.
5bd099d6-8579-4346-a480-2d72be520777
Fell, J.M.E.
8f66dc69-e247-4303-9b9c-fa01333b7cd7
Murphy, M.S.
79c6d263-7013-4194-9873-285e287541b4
Beattie, R.M.
977a2f68-2bcf-4436-87e7-28a39952adda
Sandhu, B.K.
402951ea-d922-4c8e-a603-1a769acec21b
Mitton, S.G.
bf7c3e5d-e1ac-4053-ab83-72500110e4b5
Wilson, D.C., Thomas, A.G., Croft, N.M., Newby, E., Akobeng, A.K., Sawczenko, A., Fell, J.M.E., Murphy, M.S., Beattie, R.M., Sandhu, B.K. and Mitton, S.G.
,
IBD Working Group of the British Society of Paediatric Gastroenterology, Hepatology, and Nutrition
(2010)
Systematic review of the evidence base for the medical treatment of paediatric inflammatory bowel disease.
Journal of Pediatric Gastroenterology and Nutrition, 50, .
(doi:10.1097/MPG.0b013e3181c92caa).
Abstract
Objective: to systematically review the evidence base for the medical (pharmaceutical and nutritional) treatment of paediatric inflammatory bowel disease.
Methods: key clinical questions were formulated regarding different treatment modalities used in the treatment of paediatric (not adult-onset) IBD, in particular the induction and maintenance of remission in Crohn disease and ulcerative colitis. Electronic searches were performed from January 1966 to December 2006, using the electronic search strategy of the Cochrane IBD group. Details of papers were entered on a dedicated database, reviewed in abstract form, and disseminated in full for appraisal. Clinical guidelines were appraised using the AGREE instrument and all other relevant papers were appraised using Scottish Intercollegiate Guidelines Network methodology, with evidence levels given to all papers.
Results: a total of 6285 papers were identified, of which 1255 involved children; these were entered on the database. After critical appraisal, only 103 publications met our criteria as evidence on medical treatment of paediatric IBD. We identified 3 clinical guidelines, 1 systematic review, and 16 randomised controlled trials; all were of variable quality, with none getting the highest methodological scores.
Conclusions: this is the first comprehensive review of the evidence base for the treatment of paediatric IBD, highlighting the paucity of trials of high methodological quality. As a result, the development of clinical guidelines for managing children and young people with IBD must be consensus based, informed by the best-available evidence from the paediatric literature and high-quality data from the adult IBD literature, together with the clinical expertise and multidisciplinary experience of paediatric IBD experts.
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Published date: February 2010
Identifiers
Local EPrints ID: 152407
URI: http://eprints.soton.ac.uk/id/eprint/152407
ISSN: 0277-2116
PURE UUID: a47c4a22-81be-4c58-a438-bcc4d8542274
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Date deposited: 14 May 2010 10:30
Last modified: 14 Mar 2024 01:23
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Contributors
Author:
D.C. Wilson
Author:
A.G. Thomas
Author:
N.M. Croft
Author:
E. Newby
Author:
A.K. Akobeng
Author:
A. Sawczenko
Author:
J.M.E. Fell
Author:
M.S. Murphy
Author:
R.M. Beattie
Author:
B.K. Sandhu
Author:
S.G. Mitton
Corporate Author: IBD Working Group of the British Society of Paediatric Gastroenterology, Hepatology, and Nutrition
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