The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects
The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects
To determine the effects of EPA, stearidonic acid (STA) or gamma-linolenic acid (GLA) on immune outcomes, healthy male subjects consumed one of seven oil blends for 12 weeks. EPA consumption increased the EPA content of peripheral blood mononuclear cells (PBMC). Consumption of GLA (2·0 g/d) in the absence of STA or EPA increased di-homo-GLA content in PBMC. Neither STA nor its derivative 20 : 4n-3 appeared in PBMC when STA (<1·0 g/d) was consumed. However, STA (1·0 g/d), in combination with GLA (0·9 g/d), increased the proportion of EPA in PBMC. None of the treatments altered neutrophil or monocyte phagocytosis or respiratory burst, production of inflammatory cytokines by monocytes, T lymphocyte proliferation or the delayed-type hypersensitivity response. Production of cytokines by T lymphocytes increased in all groups, with no differences among them. The proportion of lymphocytes that were natural killer cells decreased significantly in subjects receiving 2·0 g EPA or GLA/d. There were no other effects on lymphocyte sub-populations. Plasma IgE concentration decreased in most groups, but not in the control group. Plasma IgG2 concentration increased in the EPA group. Thus, EPA or GLA at a dose of 2·0 g/d have little effect on key functions of neutrophils, monocytes and T lymphocytes, although at this dose these fatty acids decrease the number of natural killer cells. At this dose EPA increases IgG2 concentrations. STA can increase immune cell EPA status, but at 1·0 g/d does not affect human immune function.
cytokine, immunoglobulin, phagocytosis, respiratory burst
893-903
Miles, E.A.
20332899-ecdb-4214-95bc-922dde36d416
Banerjee, T.
c3cbbdb7-2c1a-4071-8944-09c288631c1d
Dooper, M.M.B.W.
d5022695-6d57-484d-b012-bf2937d72f37
M'Rabet, L.
cebbdc31-ed5a-4e43-89fa-ab07dba95b12
Graus, Y.M.F.
d054d58d-2d92-4181-9601-7177fbc01842
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
2004
Miles, E.A.
20332899-ecdb-4214-95bc-922dde36d416
Banerjee, T.
c3cbbdb7-2c1a-4071-8944-09c288631c1d
Dooper, M.M.B.W.
d5022695-6d57-484d-b012-bf2937d72f37
M'Rabet, L.
cebbdc31-ed5a-4e43-89fa-ab07dba95b12
Graus, Y.M.F.
d054d58d-2d92-4181-9601-7177fbc01842
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Miles, E.A., Banerjee, T., Dooper, M.M.B.W., M'Rabet, L., Graus, Y.M.F. and Calder, P.C.
(2004)
The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects.
British Journal of Nutrition, 91 (6), .
(doi:10.1079/BJN20041131).
(PMID:15182393)
Abstract
To determine the effects of EPA, stearidonic acid (STA) or gamma-linolenic acid (GLA) on immune outcomes, healthy male subjects consumed one of seven oil blends for 12 weeks. EPA consumption increased the EPA content of peripheral blood mononuclear cells (PBMC). Consumption of GLA (2·0 g/d) in the absence of STA or EPA increased di-homo-GLA content in PBMC. Neither STA nor its derivative 20 : 4n-3 appeared in PBMC when STA (<1·0 g/d) was consumed. However, STA (1·0 g/d), in combination with GLA (0·9 g/d), increased the proportion of EPA in PBMC. None of the treatments altered neutrophil or monocyte phagocytosis or respiratory burst, production of inflammatory cytokines by monocytes, T lymphocyte proliferation or the delayed-type hypersensitivity response. Production of cytokines by T lymphocytes increased in all groups, with no differences among them. The proportion of lymphocytes that were natural killer cells decreased significantly in subjects receiving 2·0 g EPA or GLA/d. There were no other effects on lymphocyte sub-populations. Plasma IgE concentration decreased in most groups, but not in the control group. Plasma IgG2 concentration increased in the EPA group. Thus, EPA or GLA at a dose of 2·0 g/d have little effect on key functions of neutrophils, monocytes and T lymphocytes, although at this dose these fatty acids decrease the number of natural killer cells. At this dose EPA increases IgG2 concentrations. STA can increase immune cell EPA status, but at 1·0 g/d does not affect human immune function.
This record has no associated files available for download.
More information
Published date: 2004
Keywords:
cytokine, immunoglobulin, phagocytosis, respiratory burst
Identifiers
Local EPrints ID: 152481
URI: http://eprints.soton.ac.uk/id/eprint/152481
ISSN: 0007-1145
PURE UUID: b17bcda2-3e83-48eb-a8e4-88487dfbbffe
Catalogue record
Date deposited: 25 May 2011 13:20
Last modified: 14 Mar 2024 02:39
Export record
Altmetrics
Contributors
Author:
T. Banerjee
Author:
M.M.B.W. Dooper
Author:
L. M'Rabet
Author:
Y.M.F. Graus
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
