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Polyunsaturated fatty acids alter the rules of engagement

Polyunsaturated fatty acids alter the rules of engagement
Polyunsaturated fatty acids alter the rules of engagement
Evaluation of: Shaikh SR, Edidin M: Immunosuppressive effects of polyunsaturated fatty acids on antigen presentation by HLA class I molecules. J. Lipid Res. 48, 127-138 (2007).</bold> This study is the first report of the effect polyunsaturated fatty acids have on the expression of human leukocyte antigen (HLA) class I on the surface of antigen-presenting cells. Arachidonic acid (AA) and docosahexenoic acid (DHA) decreased expression of HLA class I on the surface of B lymphoblasts and this was associated with decreased lysis of those cells by cytotoxic T lymphocytes. AA and DHA decreased surface appearance of new class I molecules by slowing their flow from the endoplasmic reticulum to the Golgi. AA and DHA treatment of target B lymphoblasts also decreased the ability of cytotoxic T lymphocytes to form conjugates with them, suggesting an impairment of the close interaction between the antigen-presenting cell and T lymphocyte that is independent of HLA class I expression. AA and DHA-induced inhibition of HLA class I trafficking highlights a novel mechanism by which fatty acids affect antigen presentation.
antigen presentation, fatty acid, fish oil, immunity, t lymphocyte
27-30
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6

Calder, Philip C. (2007) Polyunsaturated fatty acids alter the rules of engagement. Future Lipidology, 2 (1), 27-30. (doi:10.2217/17460875.2.1.27).

Record type: Article

Abstract

Evaluation of: Shaikh SR, Edidin M: Immunosuppressive effects of polyunsaturated fatty acids on antigen presentation by HLA class I molecules. J. Lipid Res. 48, 127-138 (2007).</bold> This study is the first report of the effect polyunsaturated fatty acids have on the expression of human leukocyte antigen (HLA) class I on the surface of antigen-presenting cells. Arachidonic acid (AA) and docosahexenoic acid (DHA) decreased expression of HLA class I on the surface of B lymphoblasts and this was associated with decreased lysis of those cells by cytotoxic T lymphocytes. AA and DHA decreased surface appearance of new class I molecules by slowing their flow from the endoplasmic reticulum to the Golgi. AA and DHA treatment of target B lymphoblasts also decreased the ability of cytotoxic T lymphocytes to form conjugates with them, suggesting an impairment of the close interaction between the antigen-presenting cell and T lymphocyte that is independent of HLA class I expression. AA and DHA-induced inhibition of HLA class I trafficking highlights a novel mechanism by which fatty acids affect antigen presentation.

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Published date: 2007
Keywords: antigen presentation, fatty acid, fish oil, immunity, t lymphocyte

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Local EPrints ID: 152667
URI: https://eprints.soton.ac.uk/id/eprint/152667
PURE UUID: 34be2189-84d1-4df8-b498-a2314aeff181

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Date deposited: 10 Jun 2010 15:57
Last modified: 18 Jul 2017 12:53

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