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Age- and dose-dependent effects of an eicosapentaenoic acid-rich oil on cardiovascular risk factors in healthy male subjects

Age- and dose-dependent effects of an eicosapentaenoic acid-rich oil on cardiovascular risk factors in healthy male subjects
Age- and dose-dependent effects of an eicosapentaenoic acid-rich oil on cardiovascular risk factors in healthy male subjects
Supplementation with fish oils, rich in n-3 polyunsaturated fatty acids, modifies cardiovascular risk factors. However, dose-response relationships are poorly defined and whether similar effects are seen in young and older subjects is not known. This study determined the effect of supplementing the diet of young and older male subjects with different amounts of an eicosapentaenoic acid (EPA)-rich oil. Healthy young (18-42 years) and older (53-70 years) males were randomized to placebo or 1.35, 2.7 or 4.05 g EPA/day for 12 weeks. There was no effect of EPA on blood pressure or on plasma total, LDL or HDL cholesterol. EPA lowered plasma triacylglycerols, with the maximal effect at the lowest dose. Plasma lipoperoxides decreased in all groups. EPA decreased the lag time of copper-induced lipoprotein peroxidation and the ratio of reduced to total glutathione in the older subjects. The highest dose of EPA increased soluble E-selectin in young subjects, while increasing EPA tended to decrease soluble intercellular adhesion molecule 1 in young and older subjects. Young and older males will gain cardiovascular benefit from increased intake of EPA. Young males are unlikely to suffer adverse consequences from high EPA intake, whereas older males may have an increased risk of lipoprotein peroxidation.
fish oil, polyunsaturated fatty acid, cardiovascular disease, blood lipids, oxidative stress, adhesion molecules
0021-9150
159-167
Cazzola, Roberta
0d82d396-078b-456c-ac58-59717e1a6cf7
Russo-Volpe, Samantha
091cc53b-2b1f-4087-b02f-cc7986d7c2c2
Miles, Elizabeth A.
20332899-ecdb-4214-95bc-922dde36d416
Rees, Dinka
08dffec4-2d93-48da-b451-ed57fb048e33
Banerjee, Tapati
268e92f6-7802-44b4-a916-746c2433fa71
Roynette, Catherine E.
08826cd4-6fab-4904-9123-59cdeca5cdc4
Wells, Solenne J.
9e44d0d4-3138-48fc-baaf-c1f00f37f1d0
Goua, Marie
00fcfce4-7b97-4094-9fe4-43a1a069a480
Wahle, Klaus W.J.
88716de8-fff4-48bd-9434-cbb6c15ba02e
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Cestaro, Benvenuto
cc2d6f12-90fc-4087-b1ac-c353da1cdf79
Cazzola, Roberta
0d82d396-078b-456c-ac58-59717e1a6cf7
Russo-Volpe, Samantha
091cc53b-2b1f-4087-b02f-cc7986d7c2c2
Miles, Elizabeth A.
20332899-ecdb-4214-95bc-922dde36d416
Rees, Dinka
08dffec4-2d93-48da-b451-ed57fb048e33
Banerjee, Tapati
268e92f6-7802-44b4-a916-746c2433fa71
Roynette, Catherine E.
08826cd4-6fab-4904-9123-59cdeca5cdc4
Wells, Solenne J.
9e44d0d4-3138-48fc-baaf-c1f00f37f1d0
Goua, Marie
00fcfce4-7b97-4094-9fe4-43a1a069a480
Wahle, Klaus W.J.
88716de8-fff4-48bd-9434-cbb6c15ba02e
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Cestaro, Benvenuto
cc2d6f12-90fc-4087-b1ac-c353da1cdf79

Cazzola, Roberta, Russo-Volpe, Samantha, Miles, Elizabeth A., Rees, Dinka, Banerjee, Tapati, Roynette, Catherine E., Wells, Solenne J., Goua, Marie, Wahle, Klaus W.J., Calder, Philip C. and Cestaro, Benvenuto (2007) Age- and dose-dependent effects of an eicosapentaenoic acid-rich oil on cardiovascular risk factors in healthy male subjects. Atherosclerosis, 193 (1), 159-167. (doi:10.1016/j.atherosclerosis.2006.06.008).

Record type: Article

Abstract

Supplementation with fish oils, rich in n-3 polyunsaturated fatty acids, modifies cardiovascular risk factors. However, dose-response relationships are poorly defined and whether similar effects are seen in young and older subjects is not known. This study determined the effect of supplementing the diet of young and older male subjects with different amounts of an eicosapentaenoic acid (EPA)-rich oil. Healthy young (18-42 years) and older (53-70 years) males were randomized to placebo or 1.35, 2.7 or 4.05 g EPA/day for 12 weeks. There was no effect of EPA on blood pressure or on plasma total, LDL or HDL cholesterol. EPA lowered plasma triacylglycerols, with the maximal effect at the lowest dose. Plasma lipoperoxides decreased in all groups. EPA decreased the lag time of copper-induced lipoprotein peroxidation and the ratio of reduced to total glutathione in the older subjects. The highest dose of EPA increased soluble E-selectin in young subjects, while increasing EPA tended to decrease soluble intercellular adhesion molecule 1 in young and older subjects. Young and older males will gain cardiovascular benefit from increased intake of EPA. Young males are unlikely to suffer adverse consequences from high EPA intake, whereas older males may have an increased risk of lipoprotein peroxidation.

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Published date: July 2007
Keywords: fish oil, polyunsaturated fatty acid, cardiovascular disease, blood lipids, oxidative stress, adhesion molecules
Organisations: Medicine

Identifiers

Local EPrints ID: 152671
URI: https://eprints.soton.ac.uk/id/eprint/152671
ISSN: 0021-9150
PURE UUID: 28ff5bfd-68e7-4a28-8c0d-a6e828208978
ORCID for Elizabeth A. Miles: ORCID iD orcid.org/0000-0002-8643-0655

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Date deposited: 21 May 2010 13:38
Last modified: 20 Jul 2019 01:25

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Contributors

Author: Roberta Cazzola
Author: Samantha Russo-Volpe
Author: Elizabeth A. Miles ORCID iD
Author: Dinka Rees
Author: Tapati Banerjee
Author: Catherine E. Roynette
Author: Solenne J. Wells
Author: Marie Goua
Author: Klaus W.J. Wahle
Author: Benvenuto Cestaro

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