Genomic diversity between strains of the same serotype and Multilocus sequence type among pneumococcal clinical isolates

Silva, Nuno A., McClusky, Jackie, Jefferies, Johanna M.C., Hinds, Johanna M.C., Smith, Andrew, Clarke, Stuart C., Mitchell, Tim J. and Paterson, Gavin K. (2006) Genomic diversity between strains of the same serotype and Multilocus sequence type among pneumococcal clinical isolates. Infection and Immunity, 74 (6), 3513-3518. (doi:10.1128/IAI.00079-06).

Abstract

The important human pathogen Streptococcus pneumoniae is known to be a genetically diverse species. We have
used comparative genome hybridization (CGH) microarray analysis to investigate this diversity in a collection of
clinical isolates including several capsule serotype 14 pneumococci, a dominant serotype among disease isolates. We
have identified three new regions of diversity among pneumococcal isolates and, importantly, clearly demonstrate
genetic differences between strains of the same multilocus sequence type (ST) and capsule serotype. CGH may
therefore, under certain circumstances, prove to be a valuable tool to supplement current typing methods. Finally,
we show that these clonal strains with the same serotype and ST behave differently in an animal model. Strains of
the same ST and serotype therefore have important genetic and phenotypic differences.

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Contributors

Author: Stuart C. Clarke

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