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Nasal carriage of Staphylococcus aureus and endonasal activity in Wegener’s granulomatosis as compared to rheumatoid arthritis and chronic rhinosinusitis with nasal polyps

Record type: Article

Objectives: nasal colonisation with Staphylococcus aureus (S. aureus) has been implicated in Wegener`s granulomatosis (WG) disease activity. In this study, the frequency of nasal colonisation with S. aureus in WG was compared to healthy and disease control groups for the first time. Moreover, endonasal activity was correlated to colonisation.

Patients and methods: nasal carriage of S. aureus of a well-defined group of 89 patients with WG was compared to 40 patients with chronic rhinosinusitis with nasal polyps (CRS), 35 patients with rheumatoid arthritis (RA), 50 hospital staff members and 25 subjects without regular hospital contact and correlation analysis of nasal carriage and endonasal activity of WG was performed.

Results: WG patients showed significantly higher rates (72%) of nasal colonisation with S. aureus compared to CRS patients (28%) and healthy subjects without regular hospital contact (25%, 95%-CI), but not to RA patients (46%) and hospital staff members (58%). WG patients with nasal carriage of S. aureus had significantly higher endoscopically proven endonasal activity (p=0.01), significantly more often first manifestation of WG in the upper respiratory tract (p=0.02) and higher relapse-rates (p=0.052) than WG patients without such carriage.

Conclusions: endonasal activity in WG is associated with higher nasal S. aureus colonisation rates and subsequent higher relapse rates. The higher frequency of S. aureus colonisation could be a consequence of a recently shown mucosal barrier defect in WG and facilitate chronic inflammation and granuloma formation in the upper respiratory tract.

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Citation

Laudien, M., Gadola, S.D., Podschun, R., Hedderich, J., Paulsen, J., Reinhold-Keller, E., Csernok, E., Ambrosch, P., Hellmich, B., Moosig, F., Gross, W., Sahly, H. and Lamprecht, P. (2010) Nasal carriage of Staphylococcus aureus and endonasal activity in Wegener’s granulomatosis as compared to rheumatoid arthritis and chronic rhinosinusitis with nasal polyps Clinical and Experimental Rheumatology, 28, supplement 57, pp. 51-55.

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Published date: January 2010

Identifiers

Local EPrints ID: 152827
URI: http://eprints.soton.ac.uk/id/eprint/152827
ISSN: 0392-856X
PURE UUID: a0903a9b-cd92-4f12-84d9-3b4c7f974a39

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Date deposited: 17 May 2010 13:05
Last modified: 18 Jul 2017 12:53

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Contributors

Author: M. Laudien
Author: S.D. Gadola
Author: R. Podschun
Author: J. Hedderich
Author: J. Paulsen
Author: E. Reinhold-Keller
Author: E. Csernok
Author: P. Ambrosch
Author: B. Hellmich
Author: F. Moosig
Author: W. Gross
Author: H. Sahly
Author: P. Lamprecht

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