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Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: sequential analysis of a single case

Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: sequential analysis of a single case
Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: sequential analysis of a single case
We report serial genetic studies on a young female patient
initially diagnosed with asymptomatic smouldering myeloma
who progressed to symptomatic myeloma 4.5 years after presentation.

An unbalanced translocation, der(14)t(4;14)(p16;q32), was initially found in all plasma cells plus deletions of other chromosomal regions as detected by array-based comparative genomic hybridization.

Deletion of chromosome 13 was observed in a minor population of plasma cells (<20%) for the first two years, increasing to 100% of plasma cells by the time of multiple myeloma diagnosis.

Loss of 1p and a rearrangement of MYC were first observed
in a small population of plasma cells one year prior to the
clinical diagnosis of multiple myeloma, but these subclones
increased rapidly in size to become the major population
suggesting that they were directly involved in the transformation process.

This case report provides a unique insight into the mechanisms of disease progression from smouldering
multiple myeloma to multiple myeloma
smouldering multiple myeloma, plasma cell, chromosomal abnormality, progression, arrayCGH
0390-6078
1024-1028
Chiecchio, Laura
3d2f63e3-3df1-4655-8478-00ecd89d009c
Dagrada, Gian Paolo
a6e0f6d8-2aa8-4cda-a595-7d75bc5cacf8
Protheroe, Rebecca K.M.
b2c9973f-ccf1-44a4-8e37-e76ee7e8ec0b
Stockley, David M.
fd8e48fa-cd20-4326-8608-795fb84cfda4
Smith, Alastair G.
9fd8f8de-0e20-4e9b-a811-2f2fe3a32a18
Orchard, Kim H.
794654ab-d6cc-488a-ac11-c9217433c7a2
Cross, Nicholas C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Harrison, Christine J.
52da7673-509c-4b88-b92e-0c021c9c7d3e
Ross, Fiona M.
ec0958f8-b992-4e4a-b7e3-c474600390ba
Chiecchio, Laura
3d2f63e3-3df1-4655-8478-00ecd89d009c
Dagrada, Gian Paolo
a6e0f6d8-2aa8-4cda-a595-7d75bc5cacf8
Protheroe, Rebecca K.M.
b2c9973f-ccf1-44a4-8e37-e76ee7e8ec0b
Stockley, David M.
fd8e48fa-cd20-4326-8608-795fb84cfda4
Smith, Alastair G.
9fd8f8de-0e20-4e9b-a811-2f2fe3a32a18
Orchard, Kim H.
794654ab-d6cc-488a-ac11-c9217433c7a2
Cross, Nicholas C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Harrison, Christine J.
52da7673-509c-4b88-b92e-0c021c9c7d3e
Ross, Fiona M.
ec0958f8-b992-4e4a-b7e3-c474600390ba

Chiecchio, Laura, Dagrada, Gian Paolo, Protheroe, Rebecca K.M., Stockley, David M., Smith, Alastair G., Orchard, Kim H., Cross, Nicholas C.P., Harrison, Christine J. and Ross, Fiona M. (2009) Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: sequential analysis of a single case. Haematologica, 94 (7), 1024-1028. (doi:10.3324/haematol.2008.004440).

Record type: Article

Abstract

We report serial genetic studies on a young female patient
initially diagnosed with asymptomatic smouldering myeloma
who progressed to symptomatic myeloma 4.5 years after presentation.

An unbalanced translocation, der(14)t(4;14)(p16;q32), was initially found in all plasma cells plus deletions of other chromosomal regions as detected by array-based comparative genomic hybridization.

Deletion of chromosome 13 was observed in a minor population of plasma cells (<20%) for the first two years, increasing to 100% of plasma cells by the time of multiple myeloma diagnosis.

Loss of 1p and a rearrangement of MYC were first observed
in a small population of plasma cells one year prior to the
clinical diagnosis of multiple myeloma, but these subclones
increased rapidly in size to become the major population
suggesting that they were directly involved in the transformation process.

This case report provides a unique insight into the mechanisms of disease progression from smouldering
multiple myeloma to multiple myeloma

Full text not available from this repository.

More information

Published date: July 2009
Keywords: smouldering multiple myeloma, plasma cell, chromosomal abnormality, progression, arrayCGH

Identifiers

Local EPrints ID: 152929
URI: https://eprints.soton.ac.uk/id/eprint/152929
ISSN: 0390-6078
PURE UUID: b0cd4305-2110-4dc7-8f05-97adb87c1729
ORCID for Kim H. Orchard: ORCID iD orcid.org/0000-0003-2276-3925
ORCID for Nicholas C.P. Cross: ORCID iD orcid.org/0000-0001-5481-2555

Catalogue record

Date deposited: 19 May 2010 08:08
Last modified: 06 Jun 2018 12:49

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Contributors

Author: Laura Chiecchio
Author: Gian Paolo Dagrada
Author: Rebecca K.M. Protheroe
Author: David M. Stockley
Author: Alastair G. Smith
Author: Kim H. Orchard ORCID iD
Author: Christine J. Harrison
Author: Fiona M. Ross

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