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Pneumococci causing invasive disease in children prior to the introduction of pneumococcal conjugate vaccine in Scotland

Pneumococci causing invasive disease in children prior to the introduction of pneumococcal conjugate vaccine in Scotland
Pneumococci causing invasive disease in children prior to the introduction of pneumococcal conjugate vaccine in Scotland
This study aimed to determine the serotypes and sequence types (STs) of pneumococci causing paediatric invasive disease in Scotland prior to the introduction of pneumococcal conjugate vaccines (PCVs). All invasive pneumococci isolated between 2000 and 2004 from children aged less than 5 years in Scotland were used. The isolates were characterized by serotyping and multi-locus sequence typing. Two hundred and seventeen pneumococci were characterized into 22 different serogroups/types, the most common, in rank order, being 14, 19F, 6B, 18C, 23F, 9V, 4, 1, 19A and 6A. They were further genotyped into 77 different STs, the three most common being 9, 162 and 176. Common serotypes possessed multiple STs, but pneumococci of a particular clone were mostly associated with a particular serotype. The seven most common serotypes are included in the 7-valent polysaccharide conjugate vaccine (PCV7). Serotype coverage for PCV7 was 76.5% in those aged less than 5 years but increased to 88.9% for those aged 1 year. The introduction of PCV7 into the childhood immunization schedule would reduce the burden of pneumococcal disease in children, although continued surveillance of invasive pneumococcal disease will be required before, during and after the introduction of PCVs.

0022-2615
1079-1084
Clarke, Stuart C.
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Jefferies, Johanna M.C.
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Smith, Andrew J.
c3c86310-82d2-403e-9ba2-43bedbc68013
McMenamin, Jim
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Mitchell, Timothy J.
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Edwards, Giles F.S
31299b84-5ec0-4b46-a560-4b659781f9bb
Clarke, Stuart C.
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
Jefferies, Johanna M.C.
9468e292-0b41-412d-9470-944e257c7bcf
Smith, Andrew J.
c3c86310-82d2-403e-9ba2-43bedbc68013
McMenamin, Jim
c62f80f2-788d-4a1a-919b-129fe2707da0
Mitchell, Timothy J.
56ddfd4d-d6f7-4250-8864-17f156904f95
Edwards, Giles F.S
31299b84-5ec0-4b46-a560-4b659781f9bb

Clarke, Stuart C., Jefferies, Johanna M.C., Smith, Andrew J., McMenamin, Jim, Mitchell, Timothy J. and Edwards, Giles F.S (2006) Pneumococci causing invasive disease in children prior to the introduction of pneumococcal conjugate vaccine in Scotland. Journal of Medical Microbiology, 55 (8), 1079-1084. (doi:10.1099/jmm.0.46550-0).

Record type: Article

Abstract

This study aimed to determine the serotypes and sequence types (STs) of pneumococci causing paediatric invasive disease in Scotland prior to the introduction of pneumococcal conjugate vaccines (PCVs). All invasive pneumococci isolated between 2000 and 2004 from children aged less than 5 years in Scotland were used. The isolates were characterized by serotyping and multi-locus sequence typing. Two hundred and seventeen pneumococci were characterized into 22 different serogroups/types, the most common, in rank order, being 14, 19F, 6B, 18C, 23F, 9V, 4, 1, 19A and 6A. They were further genotyped into 77 different STs, the three most common being 9, 162 and 176. Common serotypes possessed multiple STs, but pneumococci of a particular clone were mostly associated with a particular serotype. The seven most common serotypes are included in the 7-valent polysaccharide conjugate vaccine (PCV7). Serotype coverage for PCV7 was 76.5% in those aged less than 5 years but increased to 88.9% for those aged 1 year. The introduction of PCV7 into the childhood immunization schedule would reduce the burden of pneumococcal disease in children, although continued surveillance of invasive pneumococcal disease will be required before, during and after the introduction of PCVs.

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Published date: 2006

Identifiers

Local EPrints ID: 153057
URI: http://eprints.soton.ac.uk/id/eprint/153057
ISSN: 0022-2615
PURE UUID: b01c2d28-8ab2-4d03-aa10-e8ce2ba2352a
ORCID for Stuart C. Clarke: ORCID iD orcid.org/0000-0002-7009-1548

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Date deposited: 21 Jun 2010 14:26
Last modified: 05 Nov 2019 01:46

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