Smaller organ mass with greater age, except for heart
Smaller organ mass with greater age, except for heart
Autopsy/cadaver data indicate that many organs and tissues are smaller in the elderly compared with young adults; however, in vivo data are lacking. The aim of this study was to determine whether the mass of specific high-metabolic-rate organs is different with increasing age, using MRI. Seventy-five healthy women (41 African-Americans and 34 Caucasians, age range 19–88 yr) and 36 men (8 African-Americans and 28 Caucasians, age range 19–84 yr) were studied. MRI-derived in vivo measures of brain, heart, kidneys, liver, and spleen were acquired. Left ventricular mass (LVM) was measured by either echocardiography or cardiac gated MRI. Total body fat mass and fat-free mass (FFM) were measured with a whole body dual-energy X-ray absorptiometry (DXA) scanner. Multiple regression analysis was used to investigate the association between the organ mass and age after adjustment for weight and height (or DXA measures of FFM), race, sex, and interactions among these variable. No statistically significant interaction was found among age, sex, and race in any regression model. Significant negative relationships between organ mass and age were found for brain (P < 0.0001), kidneys (P = 0.01), liver (P = 0.001), and spleen (P < 0.0001). A positive relationship between LVM and age was found after adjustment for FFM (P = 0.037). These findings demonstrate that age has a significant effect on brain, kidneys, liver, spleen, and heart mass. The age effect was independent of race and sex.
organs, magnetic resonance imaging, race, ethnicity
1780-1784
He, Qing
94baedd4-45f0-436e-83d4-4e2ebcd1bec3
Heshka, Stanley
a7d06276-ab84-467b-957c-aea529eac90c
Albu, Jeanine
c862a56d-e663-4ba9-afa0-ed625938bbee
Boxt, Lawrence
17dfea38-4d02-4ae3-9a17-4b29c2adf614
Kransow, Norman
e3cec3e1-03c3-4978-af86-2a14185ffc34
Elia, Marinos
964bf436-e623-46d6-bc3f-5dd04c9ef4c1
Gallagher, Dympna
056030c9-2862-4ac9-bed6-cf7045a73d61
26 March 2009
He, Qing
94baedd4-45f0-436e-83d4-4e2ebcd1bec3
Heshka, Stanley
a7d06276-ab84-467b-957c-aea529eac90c
Albu, Jeanine
c862a56d-e663-4ba9-afa0-ed625938bbee
Boxt, Lawrence
17dfea38-4d02-4ae3-9a17-4b29c2adf614
Kransow, Norman
e3cec3e1-03c3-4978-af86-2a14185ffc34
Elia, Marinos
964bf436-e623-46d6-bc3f-5dd04c9ef4c1
Gallagher, Dympna
056030c9-2862-4ac9-bed6-cf7045a73d61
He, Qing, Heshka, Stanley, Albu, Jeanine, Boxt, Lawrence, Kransow, Norman, Elia, Marinos and Gallagher, Dympna
(2009)
Smaller organ mass with greater age, except for heart.
Journal of Applied Physiology, 106, .
(doi:10.1152/japplphysiol.90454.2008).
Abstract
Autopsy/cadaver data indicate that many organs and tissues are smaller in the elderly compared with young adults; however, in vivo data are lacking. The aim of this study was to determine whether the mass of specific high-metabolic-rate organs is different with increasing age, using MRI. Seventy-five healthy women (41 African-Americans and 34 Caucasians, age range 19–88 yr) and 36 men (8 African-Americans and 28 Caucasians, age range 19–84 yr) were studied. MRI-derived in vivo measures of brain, heart, kidneys, liver, and spleen were acquired. Left ventricular mass (LVM) was measured by either echocardiography or cardiac gated MRI. Total body fat mass and fat-free mass (FFM) were measured with a whole body dual-energy X-ray absorptiometry (DXA) scanner. Multiple regression analysis was used to investigate the association between the organ mass and age after adjustment for weight and height (or DXA measures of FFM), race, sex, and interactions among these variable. No statistically significant interaction was found among age, sex, and race in any regression model. Significant negative relationships between organ mass and age were found for brain (P < 0.0001), kidneys (P = 0.01), liver (P = 0.001), and spleen (P < 0.0001). A positive relationship between LVM and age was found after adjustment for FFM (P = 0.037). These findings demonstrate that age has a significant effect on brain, kidneys, liver, spleen, and heart mass. The age effect was independent of race and sex.
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Published date: 26 March 2009
Keywords:
organs, magnetic resonance imaging, race, ethnicity
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Local EPrints ID: 153617
URI: http://eprints.soton.ac.uk/id/eprint/153617
ISSN: 8750-7587
PURE UUID: d0dec569-9193-4710-844b-fb267dee73b4
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Date deposited: 20 May 2010 12:40
Last modified: 14 Mar 2024 01:31
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Contributors
Author:
Qing He
Author:
Stanley Heshka
Author:
Jeanine Albu
Author:
Lawrence Boxt
Author:
Norman Kransow
Author:
Dympna Gallagher
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