Brain and high metabolic rate organs: contributions to resting energy expenditure beyond fat-free mass
Brain and high metabolic rate organs: contributions to resting energy expenditure beyond fat-free mass
Background: the degree to which interindividual variation in the mass of select high metabolic rate organs (HMROs) mediates variability in resting energy expenditure (REE) is unknown.
Objective: the objective was to investigate how much REE variability is explained by differences in HMRO mass in adults and whether age, sex, and race independently predict REE after adjustment for HMRO.
Design: a cross-sectional evaluation of 55 women [30 African Americans aged 48.7 ± 22.2 y (mean ± SD) and 25 whites aged 46.4 ± 17.7 y] and 32 men (8 African Americans aged 34.3 ± 18.2 y and 24 whites aged 51.3 ± 20.6 y) was conducted. Liver, kidney, spleen, heart, and brain masses were measured by magnetic resonance imaging, and fat and fat-free mass (FFM) were measured by dual-energy X-ray absorptiometry. REE was measured by indirect calorimetry.
Results: REE estimated from age (P = 0.001), race (P = 0.006), sex (P = 0.31), fat (P = 0.001), and FFM (P < 0.001) accounted for 70% (adjusted 2) of the variability in REE. The addition of trunk HMRO (P = 0.001) and brain (P = 0.006) to the model increased the explained variance to 75% and rendered the contributions of age, sex, and race statistically nonsignificant, whereas fat and FFM continued to make significant contributions (both P < 0.05). The addition of brain to the model rendered the intercept (69 kcal · kg–1 · d–1) consistent with zero, which indicated zero REE for zero body mass.
Conclusions: relatively small interindividual variation in HMRO mass significantly affects REE and reduces the role of age, race, and sex in explaining REE. Decreases in REE with increasing age may be partly related to age-associated changes in the relative size of FFM components.
907-912
Javed, Fahad
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He, Qing
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Davidson, Lance E.
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Thornton, John C.
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Albu, Jeanine
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Boxt, Lawrence
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Kransnow, Norman
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Elia, Marinos
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Kang, Patrick
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Heshka, Stanley
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Gallagher, Dympna
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April 2010
Javed, Fahad
fbe4a5b0-c259-4661-befa-da7a4befb065
He, Qing
94baedd4-45f0-436e-83d4-4e2ebcd1bec3
Davidson, Lance E.
01e822aa-5bb5-4273-9466-ca8bb09555cf
Thornton, John C.
28c2dc4e-a2b1-433f-90b3-bb3a69d6d53a
Albu, Jeanine
c862a56d-e663-4ba9-afa0-ed625938bbee
Boxt, Lawrence
17dfea38-4d02-4ae3-9a17-4b29c2adf614
Kransnow, Norman
6b1cb832-f832-465d-852b-6b6f60f6a64f
Elia, Marinos
964bf436-e623-46d6-bc3f-5dd04c9ef4c1
Kang, Patrick
692555ab-19af-4a3e-b566-0b472912ac53
Heshka, Stanley
a7d06276-ab84-467b-957c-aea529eac90c
Gallagher, Dympna
056030c9-2862-4ac9-bed6-cf7045a73d61
Javed, Fahad, He, Qing, Davidson, Lance E., Thornton, John C., Albu, Jeanine, Boxt, Lawrence, Kransnow, Norman, Elia, Marinos, Kang, Patrick, Heshka, Stanley and Gallagher, Dympna
(2010)
Brain and high metabolic rate organs: contributions to resting energy expenditure beyond fat-free mass.
American Journal of Clinical Nutrition, 91 (4), .
(doi:10.3945/ajcn.2009.28512).
Abstract
Background: the degree to which interindividual variation in the mass of select high metabolic rate organs (HMROs) mediates variability in resting energy expenditure (REE) is unknown.
Objective: the objective was to investigate how much REE variability is explained by differences in HMRO mass in adults and whether age, sex, and race independently predict REE after adjustment for HMRO.
Design: a cross-sectional evaluation of 55 women [30 African Americans aged 48.7 ± 22.2 y (mean ± SD) and 25 whites aged 46.4 ± 17.7 y] and 32 men (8 African Americans aged 34.3 ± 18.2 y and 24 whites aged 51.3 ± 20.6 y) was conducted. Liver, kidney, spleen, heart, and brain masses were measured by magnetic resonance imaging, and fat and fat-free mass (FFM) were measured by dual-energy X-ray absorptiometry. REE was measured by indirect calorimetry.
Results: REE estimated from age (P = 0.001), race (P = 0.006), sex (P = 0.31), fat (P = 0.001), and FFM (P < 0.001) accounted for 70% (adjusted 2) of the variability in REE. The addition of trunk HMRO (P = 0.001) and brain (P = 0.006) to the model increased the explained variance to 75% and rendered the contributions of age, sex, and race statistically nonsignificant, whereas fat and FFM continued to make significant contributions (both P < 0.05). The addition of brain to the model rendered the intercept (69 kcal · kg–1 · d–1) consistent with zero, which indicated zero REE for zero body mass.
Conclusions: relatively small interindividual variation in HMRO mass significantly affects REE and reduces the role of age, race, and sex in explaining REE. Decreases in REE with increasing age may be partly related to age-associated changes in the relative size of FFM components.
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Published date: April 2010
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Local EPrints ID: 153625
URI: http://eprints.soton.ac.uk/id/eprint/153625
ISSN: 0002-9165
PURE UUID: 7fc5fa14-cbba-4ed3-b3ec-bc808e3e75f4
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Date deposited: 20 May 2010 12:51
Last modified: 14 Mar 2024 01:31
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Author:
Fahad Javed
Author:
Qing He
Author:
Lance E. Davidson
Author:
John C. Thornton
Author:
Jeanine Albu
Author:
Lawrence Boxt
Author:
Norman Kransnow
Author:
Patrick Kang
Author:
Stanley Heshka
Author:
Dympna Gallagher
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