Use of the cellular model of body composition to describe changes in body water compartments after total fasting, very low calorie diet and low calorie diet in obese men
Use of the cellular model of body composition to describe changes in body water compartments after total fasting, very low calorie diet and low calorie diet in obese men
Introduction: the cellular model of body composition divides the body in body cell mass (BCM), extracellular solids and extracellular fluids. This model has been infrequently applied for the evaluation of weight loss (WL) programmes.
Objectives: (1) to assess changes in body compartments in obese men undergoing fasting, very low calorie diet (VLCD) and low calorie diet (LCD); (2) to evaluate two cellular models for the determination of changes in BCM, fat mass (FM) and body fluids.
Materials and methods: three groups of six, obese men participated in a total fast (F) for 6 days, a VLCD (2.5?MJ per day) for 3 weeks or an LCD (5.2?MJ per day) for 6 weeks. Body composition was measured at baseline and after small (~5%) and moderate (~10%) WL. FM was measured using a four-compartment model. Total body water (TBW) and extracellular water (ECW) were, respectively, measured by deuterium and sodium bromide dilution and intracellular water (ICW) calculated by difference. Two cellular models were used to measure BCM, FM and body fluids distribution.
Results: after about 5%WL changes in TBW were F=?3.2±1.2?kg (P<0.01), VLCD=?1.2±0.6?kg (P<0.01), LCD=?0.3±0.9?kg(n.s.). The contribution of TBW to total body mass loss was indirectly associated with FM loss. ECW increased during fasting (+1.5±3.1?kg, n.s.), decreased during the VLCD (?2.0±1.5?kg, P<0.05) and remained unchanged at the end of the LCD (?0.3±1.6?kg, n.s.). ICW significantly decreased during fasting (?4.7±3.9?kg, P<0.05) but did not change in the LCD and VLCD groups. The loss of BCM was more significant in the fasting group and it was directly associated with changes in ICW.
Conclusions: after a 6-day period of fasting we observed more ICW losses and less fat mobilization compared with VLCD and LCD. The cellular model of body composition is suitable for the characterization of changes in body fluids distribution during WL.
weight loss, fluid distribution, E/I ratio, multi-compartment models
908-918
Siervo, M.
beffcd7f-83c3-422e-9e21-9ac47d3b8cae
Faber, P.
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Gibney, E.R.
4652759e-95a6-4ad5-9b7d-aa0802b7910f
Lobley, G.E.
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Elia, M.
964bf436-e623-46d6-bc3f-5dd04c9ef4c1
Stubbs, R.J.
c7c92360-da93-41e2-86d3-4f4c164aedc9
Johnstone, A.M.
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May 2010
Siervo, M.
beffcd7f-83c3-422e-9e21-9ac47d3b8cae
Faber, P.
9ece510d-6c18-4aaa-8241-fe9990c0f934
Gibney, E.R.
4652759e-95a6-4ad5-9b7d-aa0802b7910f
Lobley, G.E.
a5cf1b28-6440-4894-8514-ed0dd66b2a26
Elia, M.
964bf436-e623-46d6-bc3f-5dd04c9ef4c1
Stubbs, R.J.
c7c92360-da93-41e2-86d3-4f4c164aedc9
Johnstone, A.M.
14a4654c-4dbb-4634-a882-881f6b069cd0
Siervo, M., Faber, P., Gibney, E.R., Lobley, G.E., Elia, M., Stubbs, R.J. and Johnstone, A.M.
(2010)
Use of the cellular model of body composition to describe changes in body water compartments after total fasting, very low calorie diet and low calorie diet in obese men.
International Journal of Obesity, 34 (5), .
(doi:10.1038/ijo.2010.9).
Abstract
Introduction: the cellular model of body composition divides the body in body cell mass (BCM), extracellular solids and extracellular fluids. This model has been infrequently applied for the evaluation of weight loss (WL) programmes.
Objectives: (1) to assess changes in body compartments in obese men undergoing fasting, very low calorie diet (VLCD) and low calorie diet (LCD); (2) to evaluate two cellular models for the determination of changes in BCM, fat mass (FM) and body fluids.
Materials and methods: three groups of six, obese men participated in a total fast (F) for 6 days, a VLCD (2.5?MJ per day) for 3 weeks or an LCD (5.2?MJ per day) for 6 weeks. Body composition was measured at baseline and after small (~5%) and moderate (~10%) WL. FM was measured using a four-compartment model. Total body water (TBW) and extracellular water (ECW) were, respectively, measured by deuterium and sodium bromide dilution and intracellular water (ICW) calculated by difference. Two cellular models were used to measure BCM, FM and body fluids distribution.
Results: after about 5%WL changes in TBW were F=?3.2±1.2?kg (P<0.01), VLCD=?1.2±0.6?kg (P<0.01), LCD=?0.3±0.9?kg(n.s.). The contribution of TBW to total body mass loss was indirectly associated with FM loss. ECW increased during fasting (+1.5±3.1?kg, n.s.), decreased during the VLCD (?2.0±1.5?kg, P<0.05) and remained unchanged at the end of the LCD (?0.3±1.6?kg, n.s.). ICW significantly decreased during fasting (?4.7±3.9?kg, P<0.05) but did not change in the LCD and VLCD groups. The loss of BCM was more significant in the fasting group and it was directly associated with changes in ICW.
Conclusions: after a 6-day period of fasting we observed more ICW losses and less fat mobilization compared with VLCD and LCD. The cellular model of body composition is suitable for the characterization of changes in body fluids distribution during WL.
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Published date: May 2010
Keywords:
weight loss, fluid distribution, E/I ratio, multi-compartment models
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Local EPrints ID: 153627
URI: http://eprints.soton.ac.uk/id/eprint/153627
ISSN: 0307-0565
PURE UUID: cbb887ce-9d1e-43d7-a0e4-5cbe3d97a5f9
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Date deposited: 20 May 2010 12:58
Last modified: 14 Mar 2024 01:31
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Contributors
Author:
M. Siervo
Author:
P. Faber
Author:
E.R. Gibney
Author:
G.E. Lobley
Author:
R.J. Stubbs
Author:
A.M. Johnstone
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