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Temporal analysis of invasive pneumococcal clones from Scotland illustrates fluctuations in diversity of serotype and genotype in the absence of pneumococcal conjugate vaccine

Temporal analysis of invasive pneumococcal clones from Scotland illustrates fluctuations in diversity of serotype and genotype in the absence of pneumococcal conjugate vaccine
Temporal analysis of invasive pneumococcal clones from Scotland illustrates fluctuations in diversity of serotype and genotype in the absence of pneumococcal conjugate vaccine
In September 2006, the seven-valent pneumococcal conjugate vaccine (PCV7; Prevenar) was introduced into the childhood vaccination schedule in the United Kingdom. We monitored the population of invasive pneumococci in Scotland in the 5 years preceding the introduction of PCV7 by using serogrouping, multilocus sequence typing (MLST), and eBURST analysis.

Here, we present a unique analysis of a complete national data set of invasive pneumococci over this time. We observed an increase in invasive pneumococcal disease (IPD) caused by serotypes 1, 4, and 6 and a decrease in serogroup 14-, 19-, and 23-associated disease. Analysis of sequence type (ST) data shows a significant increase in ST306, associated with serotype 1, and a decrease in ST124, associated with serotype 14. There have also been increases in the amounts of IPD caused by ST227 (serotype 1) and ST53 (serotype 8), although these increases were not found to reach significance (P = 0.08 and 0.06, respectively). In the course of the study period preceding the introduction of PCV7, we observed considerable and significant changes in serogroup and clonal distribution over time.
0095-1137
87-96
Jefferies, J.M.
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Smith, A .
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Edwards, G .
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McMenamin, J.
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Mitchell, T .
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Clarke, S.C.
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Jefferies, J.M.
9468e292-0b41-412d-9470-944e257c7bcf
Smith, A .
ff062b8d-93d3-4ad4-a3d1-3b06a2bace73
Edwards, G .
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McMenamin, J.
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Mitchell, T .
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Clarke, S.C.
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Jefferies, J.M., Smith, A ., Edwards, G ., McMenamin, J., Mitchell, T . and Clarke, S.C. (2010) Temporal analysis of invasive pneumococcal clones from Scotland illustrates fluctuations in diversity of serotype and genotype in the absence of pneumococcal conjugate vaccine. Journal of Clinical Microbiology, 48 (1), 87-96. (doi:10.1128/JCM.01485-09).

Record type: Article

Abstract

In September 2006, the seven-valent pneumococcal conjugate vaccine (PCV7; Prevenar) was introduced into the childhood vaccination schedule in the United Kingdom. We monitored the population of invasive pneumococci in Scotland in the 5 years preceding the introduction of PCV7 by using serogrouping, multilocus sequence typing (MLST), and eBURST analysis.

Here, we present a unique analysis of a complete national data set of invasive pneumococci over this time. We observed an increase in invasive pneumococcal disease (IPD) caused by serotypes 1, 4, and 6 and a decrease in serogroup 14-, 19-, and 23-associated disease. Analysis of sequence type (ST) data shows a significant increase in ST306, associated with serotype 1, and a decrease in ST124, associated with serotype 14. There have also been increases in the amounts of IPD caused by ST227 (serotype 1) and ST53 (serotype 8), although these increases were not found to reach significance (P = 0.08 and 0.06, respectively). In the course of the study period preceding the introduction of PCV7, we observed considerable and significant changes in serogroup and clonal distribution over time.

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Published date: January 2010

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Local EPrints ID: 154117
URI: http://eprints.soton.ac.uk/id/eprint/154117
ISSN: 0095-1137
PURE UUID: ad3227d0-cfcd-4321-903c-c923d62f019c
ORCID for S.C. Clarke: ORCID iD orcid.org/0000-0002-7009-1548

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Date deposited: 24 May 2010 13:10
Last modified: 14 Mar 2024 02:51

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Contributors

Author: J.M. Jefferies
Author: A . Smith
Author: G . Edwards
Author: J. McMenamin
Author: T . Mitchell
Author: S.C. Clarke ORCID iD

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